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Human IL-15RAandIL-15 (C-Fc) Protein

Recombinant Human Interleukin-15 Receptor Alpha and Interleukin-15 Fusion Protein is produced by our Mammalian expression system and the target gene encoding Ile31-Asp96andAsn49-Ser162(Asn120Asp) is expressed with a Fc tag at the C-terminus.
5/5

¥365.00

货号:12250

规格: 50 μg

库存状态:In Stock

           产品描述          
货号:   12250
产品全名:   人 IL-15RAandIL-15 (C-Fc) 蛋白
规格:   10/50/100 µg
基因符号   IL15RAandIL15;Interleukin-15;IL-15;IL15;IL-15 receptor subunit alpha;IL-15RA;IL-15R-alpha;interleukin-15 receptor subunit alpha
目标蛋白:    IL-15RAandamp;IL-15
UNIPROT ID:    Q13261;P40933
描述:   Recombinant Human Interleukin-15 Receptor Alpha and Interleukin-15 Fusion Protein is produced by our Mammalian expression system and the target gene encoding Ile31-Asp96andAsn49-Ser162(Asn120Asp) is expressed with a Fc tag at the C-terminus.
背景:     IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL-15RA with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor, but not the alpha subunit of the IL2 receptor. IL-15 is structurally and functionally related to IL-2. Both cytokines share some subunits of receptors, allowing them to compete for and negatively regulate each other's activity. The number of CD8 memory T cells is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs.
物种/宿主:    HEK293
分子量:   46.9 KDa
分子特征:   Not available
纯化:   Greater than 95% as determined by reducing SDS-PAGE.
Formulation & Reconstitution:   Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
储存和运输:   Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Greater than 95% as determined by reducing SDS-PAGE.
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