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Rac Pull-Down Activation Assay Kit

Rac Pull-Down Activation Assay Kit
5/5

$6,800.00

货号:80501

规格: 30 Assays

库存状态:In Stock

           产品描述          

Rac Pull-Down Activation Assay Kit

Cat. # 80501

Introduction

A. Background
Small GTPases are a super-family of cellular signaling regulators. Rac belongs to the Rho sub-family of GTPases that regulate cell motility, cell division, and gene transcription. GTP binding increases the activity of Rac, and the hydrolysis of GTP to GDP renders it inactive.
Currently the activation of Rac proteins is assayed with the binding of GTP-bound Rac to the p21-binding domain (PBD) of p21-activated protein kinase (PAK). This method is based on the observation that the active, GTP-bound Rac could bind to the PBD of PAK. However, the reproducibility of this method is poor. This is partially due to the relatively quick hydrolysis of GTP to GDP during the assay procedure, and the low binding affinity of PBD to Rac-GTP.
The Rac Activation Assay Kit is based on the configuration-specific monoclonal antibody that specifically recognizes Rac-GTP, but not Rac-GDP. Given the high affinity of monoclonal antibodies to their antigens, the activation assay could be performed in a much shorter time. This assay provides the reliable results with consistent reproducibility.
These anti-Rac-GTP monoclonal antibody can also be used to monitor the activation of Rac in cells and in tissues by immunohistochemistry.
B. Assay Principle
The Rac Activation Assay Kit uses configuration-specific anti-Rac-GTP Mouse monoclonal antibody to measure Rac-GTP levels in cell extracts or in vitro GTPγS loading Rac activation assays. Anti-Rac-GTP mouse monoclonal antibody is first incubated with cell lysates containing Rac-GTP. Next, the GTP-bound Rac is pulled down by protein A/G agarose. Finally, the precipitated Rac-GTP is detected through immunoblot analysis using Anti-Rac Rabbit Polyclonal Antibody.
The anti-Rac-GTP monoclonal antibody can also be used to monitor the activation of Rac in cells and in tissues by immunohistochemistry.
C. Kit Components
1. Anti-Rac-GTP Mouse Monoclonal Antibody (Cat. # 26903): 30 µL (1 mg/ml) in PBS, pH 7.4, containing 50% glycerol. This antibody specifically recognizes Rac-GTP from all vertebrates.
2. Protein A/G Agarose (Cat. # 30301): 600 µL of 50% slurry.
3. 5X Assay/Lysis Buffer (Cat. # 30302): 30 mL of 250 mM Tris-HCl, pH 8, 750 mM NaCl, 50 mM MgCl2, 5 mM EDTA, 5% Triton X-100.
4. Anti-Rac Rabbit Polyclonal Antibody (Cat. # 21003): 50 µL (1mg/mL) in PBS, pH 7.4, contained 50% glycerol.
5. 100X GTPγS (Cat. # 30303): 50 µl at 10 mM, use 5 µL of GTPγS for  GTP-labeling of 0.5 mL of cell lysate.
6. 100X GDP (Cat. # 30304): 50 µl at 100 mM, use 5 µL of GDP for GDP-labeling of 0.5 mL of cell lysate.
7. HRP-Goat Anti-Rabbit IgG (Cat. #29002): 50 µL (0.4 mg/mL) in PBS, pH 7.4, contained 50% glycerol.
D. Materials Needed but Not Supplied
1. Stimulated and non-stimulated cell lysates
2. Protease inhibitors
3. 4 °C tube rocker or shaker
4. 0.5 M EDTA at pH 8.0
5. 1.0 M MgCl2
6. 2X reducing SDS-PAGE sample buffer
7. Electrophoresis and immunoblotting systems
8. Immunoblotting wash buffer such as TBST (10 mM Tris-HCl, pH 7.4, 0.15 M NaCl, 0.05%  Tween-20)
9. Immunoblotting blocking buffer (TBST containing 5% Non-fat Dry Milk or 3% BSA)
10. ECL Detection Reagents
E. Example Results
The following figure demonstrates example results seen with the Rac Activation Assay Kit. For reference only.
Rac Activation Assay Kit Rac Activation Assay. MEF cells were treated with (lane 2) or without (lane 1) PDGF. Cell lysates were incubated with an anti-Rac-GTP monoclonal antibody (Cat. # 26903) (top panel). The precipitated active Rac was immunoblotted with an anti-Rac rabbit polyclonal antibody (Cat # 21003). The bottom panel shows the Western blot with anti-Rac of the cell lysates used (5% of that used in the top panel).

Assay Procedure

A. Reagent Preparation
1X Assay/Lysis Buffer: Mix the 5X Stock (Cat. # 30302) briefly and dilute with deionized water to make 1X buffer. Just prior to usage, add protease inhibitors such as 1 mM PMSF, 10 µg/mL leupeptin, and 10 µg/mL aprotinin.
B. Sample Preparation
Adherent Cells
1. Culture cells (one 10-cm plate, ~107 cells) to approximately 80-90% confluence. Stimulate the cells with activator or inhibitor as desired.
2. Aspirate the culture media and wash twice with ice-cold PBS.
3. Completely remove the final PBS wash and add ice-cold 1X Assay/Lysis Buffer (See Reagent Preparation) to the cells (0.5-1 mL per 10 cm tissue culture plate).
4. Place the culture plates on ice for 10-20 minutes.
5. Detach the cells from the plates by scraping with a cell scraper.
6. Transfer the lysates to appropriate size tubes and place on ice.
7. If nuclear lysis occurs, the cell lysates may become viscous and difficult to pipette. If this occurs, lysates can be passed through a 27½-gauge syringe needle 3-4 times to shear the genomic DNA.
8. Clear the lysates by centrifuging at 12,000 x g and 4°C for 10 minutes.
9. Collect the supernatant and store the sample (~1-2 mg of total protein) on ice for immediate use, or snap freeze and store at -70°C for future use.
Suspension Cells
1. Culture cells and stimulate with activator or inhibitor as desired.
2. Perform a cell count and then pellet the cells through centrifugation.
3. Aspirate the culture media and wash twice with ice-cold PBS.
4. Completely remove the final PBS wash and add ice-cold 1X Assay/Lysis Buffer (See Reagent Preparation) to the cell pellet (0.5-1 mL per 107 cells).
5. Lyse the cells by repeated pipetting.
6. Transfer the lysates to appropriate size tubes and place them on ice.
7. If nuclear lysis occurs, the cell lysates may become viscous and difficult to pipette. If this occurs, lysates can be passed through a 27½-gauge syringe needle 3-4 times to shear the genomic DNA.
8. Clear the lysates by centrifuging at 12,000 x g and 4°C for 10 minutes.
9. Collect the supernatant and store sample on ice for immediate use, or snap freeze and store at -70°C for future use.
C. In vitro GTPγS/GDP Protein for Positive and Negative controls
Note: In vivo stimulation of cells will activate approximately 10% of the available Rac, whereas in vitro GTPγS protein loading will activate nearly 90% of Rac.
1. Aliquot 0.5 mL of cell extract (or 1 µg of purified Rac protein) into two microcentrifuge tubes.
2. To each tube, add 20 µL of 0.5 M EDTA (final concentration of 20 mM).
3. Add 5 µL of 100 X GTPγS (Cat. # 30303) to the first tube as a positive control.
4. Add 5 µL of 100 X GDP (Cat. # 30304) to the second tube as a negative control.
5. Incubate both tubes at 30°C for 30 minutes with agitation.
6. Stop loading by placing the tubes on ice and adding 32.5 µL of 1 M MgCl2 (final concentration of 60 mM).
D. Affinity Precipitation of Activated G Protein
1. Aliquot 0.5-1 mL of cell lysates (about 1 mg of total cellular protein) to a microcentrifuge tube.
2. Adjust the volume to 1 mL with 1X Assay/Lysis Buffer (See Reagent Preparation).
3. Add 1 µL anti-Rac-GTP antibody (Cat. # 26903).
4. Prepare the protein A/G Agarose bead slurry (Cat. # 30301) by resuspending through vertexing or titrating.
5. Quickly add 20 µL of resuspended bead slurry to above tube.
6. Incubate the tube at 4°C for 1 hour with gentle agitation.
7. Pellet the beads through centrifugation at 5,000 x g for 1 min.
8. Aspirate and discard the supernatant (making sure not to disturb or remove the bead pellet).
9. Wash the beads 3 times with 0.5 mL of 1X Assay/Lysis Buffer, centrifuging and aspirating each time.
10. After the third wash, pellet the beads through centrifugation and carefully remove all the supernatant.
11. Resuspend the bead pellet in 20 µL of 2X reducing SDS- PAGE sample buffer.
12. Boil the sample for 5 minutes.
13. Centrifuge it at 5,000 x g for 10 seconds.
E. Western Blot Analysis
1. Load 15 µL/well of pull-down supernatant to a polyacrylamide gel (17%). It is recommended to include a pre-stained MW standard (as an indicator of a successful transfer in step 3 below).
2. Perform SDS-PAGE following the manufacturer’s instructions.
3. Transfer the gel proteins to a PVDF or nitrocellulose membrane following the manufacturer’s instructions.
Note: Steps 4-11 are at room temperature with agitation
4. Following electroblotting, immerse the PVDF membrane in 100% Methanol for 15 seconds, and then allow it to dry at room temperature for 5 minutes.
Note: If Nitrocellulose is used instead of PVDF, step 4 Should be skipped.
5. Block the membrane with 5% non-fat dry milk or 3% BSA in TBST for 1 hr at room temperature with constant agitation.
6. Wash the blotted membrane three times with TBST, 5 minutes each time.
7. Incubate the membrane with Anti-Rac Rabbit Polyclonal Antibody (Cat. # 21003), which is freshly diluted 1:50~500 (depending on the amount of Rac proteins in your sample) in 5% non-fat dry milk or 3% BSA in TBST, for 1-2 hr at room temperature with constant agitation or at 4°C overnight.
8. Wash the blotted membrane three times with TBST, 5 minutes each time.
9. Incubate the membrane with a secondary antibody (Cat. # 29002), which is freshly diluted 1:1000 in 5% non-fat dry milk or 3% BSA in TBST, for 1 hr at room temperature with constant agitation.
10. Wash the blotted membrane three times with TBST, 5 minutes each time.
11. Use the detection method of your choice such as ECL.
           引用文献          

<table>
<tbody>
<tr><td><strong>001.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/36584745/” target=”_blank” rel=”noopener”>Downregulation of CYRI-B promotes migration, invasion and EMT by activating the Rac1-STAT3 pathway in gastric cancer</a><br/>Exp Cell Res. 2023 &emsp;&emsp;PMID:&nbsp;36584745</td><tr/>
<tr><td><strong>002.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171644/” target=”_blank” rel=”noopener”>Glucuronoxylomannan intranasal challenge prior to Cryptococcus neoformans pulmonary infection enhances cerebral cryptococcosis in rodents</a><br/>PLoS Pathog. 2023 &emsp;&emsp;PMID:&nbsp;37115795</td><tr/>
<tr><td><strong>003.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/37298689/” target=”_blank” rel=”noopener”>Tumoricidal Activity of Simvastatin in Synergy with RhoA Inactivation in Antimigration of Clear Cell Renal Cell Carcinoma Cells</a><br/>Int J Mol Sci. 2023 &emsp;&emsp;PMID:&nbsp;37298689</td><tr/>
<tr><td><strong>004.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/36446524/” target=”_blank” rel=”noopener”>Loss of cell-cell adhesion triggers cell migration through Rac1-dependent ROS generation</a><br/>Life Sci Alliance. 2022 &emsp;&emsp;PMID:&nbsp;36446524</td><tr/>
<tr><td><strong>005.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/36598812/” target=”_blank” rel=”noopener”>The scaffold RhoGAP protein ARHGAP8/BPGAP1 synchronizes Rac and Rho signaling to facilitate cell migration</a><br/>Life Sci Alliance. 2022 &emsp;&emsp;PMID:&nbsp;36598812</td><tr/>
<tr><td><strong>006.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/36744839/” target=”_blank” rel=”noopener”>Rac1 and Rac3 GTPases and TPC2 are required for axonal outgrowth and migration of cortical interneurons</a><br/>J Cell Sci. 2023 &emsp;&emsp;PMID:&nbsp;36744839</td><tr/>
<tr><td><strong>007.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/36598812/” target=”_blank” rel=”noopener”>The Scaffold RhoGAP Protein ARHGAP8/ BPGAP1 Synchronizes Rac and Rho Signaling to Facilitate Cell Migration</a><br/>Mol Biol Cell. 2023&emsp;&emsp;PMID:&nbsp;36598812</td><tr/>
<tr><td><strong>008.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/36508052/” target=”_blank” rel=”noopener”>Catalpol inhibits hepatic stellate cell activation by reducing the formation and changing the contents of hepatocyte-derived extracellular vesicles</a><br/>J Cell Commun Signal. 2022&emsp;&emsp;PMID:&nbsp;36508052</td><tr/>
<tr><td><strong>009.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/36584745/” target=”_blank” rel=”noopener”>Downregulation of CYRI-B promotes migration, invasion and EMT by activating the Rac1-STAT3 pathway in gastric cancer</a><br/>Exp Cell Res. 2022&emsp;&emsp;PMID:&nbsp;36584745</td></tr>
<tr><td><strong>010.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/36446524/” target=”_blank” rel=”noopener”>Loss of cell–cell adhesion triggers cell migration through Rac1-dependent ROS generation</a><br/>Life Sci Alliance. 2022&emsp;&emsp;PMID:&nbsp;36446524</td><tr/>
<tr><td><strong>011.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/36508052/” target=”_blank” rel=”noopener”>Catalpol inhibits hepatic stellate cell activation by reducing the formation and changing the contents of hepatocyte-derived extracellular vesicles</a><br/>J Cell Commun Signal. 2022&emsp;&emsp;PMID:&nbsp;36508052</td><tr/>
<tr><td><strong>012.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582797/” target=”_blank” rel=”noopener”>Cardiac inducing colonies halt fibroblast activation and induce cardiac/endothelial cells to move and expand via paracrine signaling</a><br/>Mol Biol Cell. 2022&emsp;&emsp;PMID:&nbsp;35653297</td><tr/>
<tr><td><strong>013.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760284/” target=”_blank” rel=”noopener”>Inhibition of Rac1 attenuates radiation-induced lung injury while suppresses lung tumor in mice</a><br/>Cell Death Discov. 2022&emsp;&emsp;PMID:&nbsp;35031595</td><tr/>
<tr><td><strong>014.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305120/” target=”_blank” rel=”noopener”>Smooth muscle Rac1 contributes to pulmonary hypertension</a><br/>BJP. 2022&emsp;&emsp;PMID:&nbsp;35064565</td><tr/>
<tr><td><strong>015.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/35074515/” target=”_blank” rel=”noopener”>Rac1 mediates cadherin-11 induced cellular pathogenic processes in aortic valve calcification</a><br/>Cardiovasc Pathol. 2022&emsp;&emsp;PMID:&nbsp;35074515</td><tr/>
<tr><td><strong>016.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/35104805/” target=”_blank” rel=”noopener”>A Portable Controllable Compressive Stress Device to Monitor Human Breast Cancer Cell Protrusions at Single-Cell Resolution</a><br/>J Clin Invest. 2022&emsp;&emsp;PMID:&nbsp;35104805</td><tr/>
<tr><td><strong>017.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8845157/” target=”_blank” rel=”noopener”>Hepatic Ischemia-reperfusion Injury in Mice was Alleviated by Rac1 Inhibition – More Than Just ROS-inhibition</a><br/>J Clin Transl Hepatol. 2022&emsp;&emsp;PMID:&nbsp;35233372</td><tr/>
<tr><td><strong>018.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907972/” target=”_blank” rel=”noopener”>Targeting the ASMase/S1P pathway protects from sortilin-evoked vascular damage in hypertension</a><br/>J Neuroinflammation. 2022&emsp;&emsp;PMID:&nbsp;35284404</td><tr/>
<tr><td><strong>019.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/35420656/” target=”_blank” rel=”noopener”>Planar cell polarity-dependent asymmetric organization of microtubules for polarized positioning of the basal body in node cells</a><br/>Development. 2022&emsp;&emsp;PMID:&nbsp;35420656</td><tr/>
<tr><td><strong>020.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245039/” target=”_blank” rel=”noopener”>Time of Day-Dependent Alteration of Hippocampal Rac1 Activation Regulates Contextual Fear Memory in Rats</a><br/>Front Mol Neurosci. 2022&emsp;&emsp;PMID:&nbsp;35782392</td><tr/>
<tr><td><strong>021.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281167/” target=”_blank” rel=”noopener”>Transient neuroinflammation following surgery contributes to long-lasting cognitive decline in elderly rats via dysfunction of synaptic NMDA receptor</a><br/>Front Bioeng Biotechnol. 2022&emsp;&emsp;PMID:&nbsp;35831873</td><tr/>
<tr><td><strong>022.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308268/” target=”_blank” rel=”noopener”>ARHGEF37 overexpression promotes extravasation and metastasis of hepatocellular carcinoma via directly activating Cdc42</a><br/>J Exp Clin Cancer Res. 2022&emsp;&emsp;PMID:&nbsp;35869555</td><tr/>
<tr><td><strong>023.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/36129975/” target=”_blank” rel=”noopener”>Organoid-on-a-chip model of human ARPKD reveals mechanosensing pathomechanisms for drug discovery</a><br/>Sci Adv. 2022&emsp;&emsp;PMID:&nbsp; 36129975</td><tr/>
<tr><td><strong>024.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492659/” target=”_blank” rel=”noopener”>Differential dysregulation of granule subsets in WASH-deficient neutrophil leukocytes resulting in inflammation</a><br/>Nat Commun. 2022&emsp;&emsp;PMID:&nbsp; 36130971</td><tr/>
<tr><td><strong>025.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496593/” target=”_blank” rel=”noopener”>The Pro-Fibrotic Response to Lens Injury Is Signaled in a PI3K Isoform-Specific Manner</a><br/>Biomolecules. 2022&emsp;&emsp;PMID:&nbsp;36139020</td><tr/>
<tr><td><strong>026.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562403/” target=”_blank” rel=”noopener”>Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage</a><br/>Cell Death Dis. 2022&emsp;&emsp;PMID:&nbsp;36229446</td><tr/>
<tr><td><strong>027.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/36284029/” target=”_blank” rel=”noopener”>Critical role of mitogen-inducible gene 6 in restraining endothelial cell permeability to maintain vascular homeostasis</a><br/>J Cell Commun Signal. 2022&emsp;&emsp;PMID:&nbsp;36284029</td><tr/>
<tr><td><strong>028.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599176/” target=”_blank” rel=”noopener”>PTEN Protein Phosphatase Activity Is Not Required for Tumour Suppression in the Mouse Prostate</a><br/>Biomolecules. 2022&emsp;&emsp;PMID:&nbsp;36291720</td><tr/>
<tr><td><strong>029.&emsp;</strong><a href=”https://www.sciencedirect.com/science/article/pii/S2667325822001996″ target=” blank” rel=”noopener”>Dock4 is required for the maintenance of cochlear hair cells and hearing function</a><br/>Fundamental Research. 2022</td></tr>
<tr><td><strong>030.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927959/” target=”_blank” rel=”noopener”>A role of PIEZO1 in iron metabolism in mice and humans.</a><br/>Cell. 2021&emsp;&emsp;PMID:&nbsp;33571427</td><tr/>
<tr><td><strong>031.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/33397922/” target=”_blank” rel=”noopener”>A RAC-GEF network critical for early intestinal tumourigenesis</a><br/>Nat Commun. 2021&emsp;&emsp;PMID:&nbsp;33397922</td><tr/>
<tr><td><strong>032.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/33527537/” target=” blank” rel=”noopener”>Arhgef6 (alpha-PIX) cytoskeletal regulator signals to GTPases and Cofilin to couple T cell migration speed and persistence</a><br/>J Leukoc Biol. 2021&emsp;&emsp;PMID:&nbsp;33527537</td><tr/>
<tr><td><strong>033.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982925/” target=”_blank” rel=”noopener”>Essential role of smooth muscle Rac1 in severe asthma-associated airway remodelling</a><br/>Thorax. 2021&emsp;&emsp;PMID:&nbsp;33542087</td><tr/>
<tr><td><strong>034.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865553/” target=”_blank” rel=”noopener”>7-ketocholesterol induces endothelial-mesenchymal transition and promotes fibrosis: implications in neovascular age-related macular degeneration and treatment</a><br/>Angiogenesis. 2021&emsp;&emsp;PMID:&nbsp;33646466</td><tr/>
<tr><td><strong>035.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/33852856/” target=”_blank” rel=”noopener”> Dihydroceramide desaturase regulates the compartmentalization of Rac1 for neuronal oxidative stress</a><br/>Cell Rep. 2021&emsp;&emsp;PMID:&nbsp;33852856</td><tr/>
<tr><td><strong>036.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085119/” target=”_blank” rel=”noopener”>Apoptotic cells in mouse blastocysts are eliminated by neighbouring blastomeres</a><br/>Sci Rep. 2021&emsp;&emsp;PMID:&nbsp;33927296</td><tr/>
<tr><td><strong>037.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/33973520/” target=”_blank” rel=”noopener”> EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice</a><br/>eLife. 2021&emsp;&emsp;PMID:&nbsp;33973520</td><tr/>
<tr><td><strong>038.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483510/” target=”_blank” rel=”noopener”>MFG‐E8 Regulates Vascular Smooth Muscle Cell Migration Through Dose‐Dependent Mediation of Actin Polymerization</a><br/>J Am Heart Assoc. 2021&emsp;&emsp;PMID:&nbsp;34041925</td><tr/>
<tr><td><strong>039.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276982/” target=”_blank” rel=”noopener”>Hydrostatic mechanical stress regulates growth and maturation of the atrioventricular valve</a><br/>Development. 2021&emsp;&emsp;PMID:&nbsp;34086041</td><tr/>
<tr><td><strong>040.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/34212532/” target=” blank” rel=”noopener”>Flexible Ultrasonic Patch for Accelerating Chronic Wound Healing</a><br/>Adv Healthc Mater. 2021&emsp;&emsp;PMID:&nbsp;34212532</td><tr/>
<tr><td><strong>041.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452869/” target=”_blank” rel=”noopener”>Deregulated Rac1 Activity in Neural Crest Controls Cell Proliferation&#44; Migration and Differentiation During Midbrain Development</a><br/>Front Cell Dev Biol. 2021&emsp;&emsp;PMID:&nbsp;34557485</td><tr/>
<tr><td><strong>042.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604770/” target=”_blank” rel=”noopener”>Decoupling Tumor Cell Metastasis From Growth By Cellular Pilot Protein TNFAIP8</a><br/>Oncogene. 2021&emsp;&emsp;PMID:&nbsp;34608264</td><tr/>
<tr><td><strong>043.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/34626585/” target=” blank” rel=”noopener”>Scavenger receptor MARCO contributes to macrophage phagocytosis and clearance of tumor cells</a><br/>Exp Cell Res. 2021&emsp;&emsp;PMID:&nbsp;34626585</td><tr/>
<tr><td><strong>044.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595285/” target=”_blank” rel=”noopener”>Geranylgeraniol Restores Zoledronic Acid-Induced Efferocytosis Inhibition in Bisphosphonate-Related Osteonecrosis of the Jaw</a><br/>Front Cell Dev Biol. 2021&emsp;&emsp;PMID:&nbsp;34805177</td><tr/>
<tr><td><strong>045.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/34880503/” target=”_blank” rel=”noopener”>Collective durotaxis along a self-generated stiffness gradient in vivo</a><br/>Nature. 2021&emsp;&emsp;PMID:&nbsp;34880503</td><tr/>
<tr><td><strong>046.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712650/” target=”_blank” rel=”noopener”>Sustained Release of Gas6 via mPEG-PLGA Nanoparticles Enhances the Therapeutic Effects of MERTK Gene Therapy in RCS Rats</a><br/>Front Med (Lausanne). 2021&emsp;&emsp;PMID:&nbsp;34970569</td><tr/>
<tr><td><strong>047.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733199/” target=”_blank” rel=”noopener”>yk-MyD88 Axis Is a Critical Determinant of Inflammatory-Response in Activated Macrophages</a><br/>Front Immunol. 2021&emsp;&emsp;PMID:&nbsp;35003083</td><tr/>
<tr><td><strong>048.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973152/” target=”_blank” rel=”noopener”>Voltage‐dependent activation of Rac1 by Nav1.5 channels promotes cell migration</a><br/>J Cell Physiol. 2020&emsp;&emsp;PMID:&nbsp;31612502</td><tr/>
<tr><td><strong>049.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020796/” target=”_blank” rel=”noopener”>Dysregulation of Rac or Rho elicits death of motor neurons and activation of these GTPases is altered in the G93A mutant hSOD1 mouse model of amyotrophic lateral sclerosis</a><br/>Neurobiol Dis. 2020&emsp;&emsp;PMID:&nbsp;31931138</td><tr/>
<tr><td><strong>050.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082877/” target=”_blank” rel=”noopener”>Statins Disrupt Macrophage Rac1 Regulation Leading to Increased Atherosclerotic Plaque Calcification</a><br/>Arterioscler Thromb Vasc Biol. 2020&emsp;&emsp;PMID:&nbsp;31996022</td><tr/>
<tr><td><strong>051.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992649/” target=”_blank” rel=”noopener”>Spaced Training Enhances Contextual Fear Memory via Activating Hippocampal 5-HT2A Receptors</a><br/>Front Mol Neurosci. 2020&emsp;&emsp;PMID:&nbsp;32038159</td><tr/>
<tr><td><strong>052.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289320/” target=”_blank” rel=”noopener”>Glycolysis Independent Glucose Metabolism Distinguishes TE from ICM Fate During Mammalian Embryogenesis</a><br/>Dev Cell. 2020&emsp;&emsp;PMID:&nbsp;32197068</td><tr/>
<tr><td><strong>053.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125138/” target=”_blank” rel=”noopener”>Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation</a><br/>Nat Commun. 2020&emsp;&emsp;PMID:&nbsp;32246016</td><tr/>
<tr><td><strong>054.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170861/” target=” blank” rel=”noopener”>The TIPE Molecular Pilot That Directs Lymphocyte Migration in Health and Inflammation</a><br/>Sci Rep. 2020&emsp;&emsp;PMID:&nbsp;32313148</td><tr/>
<tr><td><strong>055.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/32314182/” target=”_blank” rel=”noopener”>Rac1 activation in human breast carcinoma as a prognostic factor associated with therapeutic resistance</a><br/>Breast Cancer. 2020&emsp;&emsp;PMID:&nbsp;32314182</td><tr/>
<tr><td><strong>056.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/32320683/” target=”_blank” rel=”noopener”>Rac1-dependent phagocytosis of apoptotic cells by oral squamous cell carcinoma cells: A possible driving force for tumor progression</a><br/>Experimental Cell Research. 2020&emsp;&emsp;PMID:&nbsp;32320683</td><tr/>
<tr><td><strong>057.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353033/” target=”_blank” rel=”noopener”>PGI2 Analog Attenuates Salt-Induced Renal Injury through the Inhibition of Inflammation and Rac1-MR Activation</a><br/>Int J Mol Sci. 2020&emsp;&emsp;PMID:&nbsp;32580367</td><tr/>
<tr><td><strong>058.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/32592615/” target=” blank” rel=”noopener”>The laminin-211-derived PPFEGCIWN motif accelerates wound reepithelialization and increases phospho-FAK-Tyr397 and Rac1-GTP levels in a rat excisional wound splinting model</a><br/>J Tissue Eng Regen Med. 2020&emsp;&emsp;PMID:&nbsp; 32592615</td><tr/>
<tr><td><strong>059.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380942/” target=”_blank” rel=”noopener”>Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration</a><br/>eLife. 2020&emsp;&emsp;PMID:&nbsp;32705984</td><tr/>
<tr><td><strong>060.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530064/” target=” blank” rel=”noopener”>TIQGAP1 Causes Choroidal Neovascularization by Sustaining VEGFR2-mediated Rac1 Activation</a><br/>Angiogenesis. 2020&emsp;&emsp;PMID:&nbsp;32783108</td><tr/>
<tr><td><strong>061.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491649/” target=”_blank” rel=”noopener”>Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton</a><br/>J Cell Sci. 2020&emsp;&emsp;PMID:&nbsp;32788232</td><tr/>
<tr><td><strong>062.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/30659265/” target=” blank” rel=”noopener”>Oxygen sensor FIH inhibits HACE1-dependent ubiquitination of Rac1 to enhance metastatic potential in breast cancer cells</a><br/>Oncogene. 2019&emsp;&emsp;PMID:&nbsp;30659265</td><tr/>
<tr><td><strong>063.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543538/” target=”_blank” rel=”noopener”>The trafficking protein JFC1 regulates Rac1-GTP localization at the uropod controlling neutrophil chemotaxis and in vivo migration</a><br/>J Leukoc Biol. 2019&emsp;&emsp;PMID:&nbsp;30748033</td><tr/>
<tr><td><strong>064.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/30788390/” target=”_blank” rel=”noopener”>Regulation of cytoskeleton and adhesion signaling in osteoclasts by tetraspanin CD82</a><br/>Bone Reports. 2019&emsp;&emsp;PMID:&nbsp;30788390</td><tr/>
<tr><td><strong>065.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/30797592/” target=” blank” rel=”noopener”>Inhibition of fascin in cancer and stromal cells blocks ovarian cancer metastasis</a><br/>Gynecol Oncol. 2019&emsp;&emsp;PMID:&nbsp;30797592</td><tr/>
<tr><td><strong>066.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/30833420/” target=” blank” rel=”noopener”>Epigenetic Regulation of the PTEN-AKT-RAC1 Axis by G9a Is Critical for Tumor Growth in Alveolar Rhabdomyosarcoma</a><br/>Cancer Res. 2019&emsp;&emsp;PMID:&nbsp;30833420</td><tr/>
<tr><td><strong>067.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447549/” target=”_blank” rel=”noopener”>In vivo topology converts competition for cell-matrix adhesion into directional migration</a><br/>Nat Commun. 2019&emsp;&emsp;PMID:&nbsp;30944331</td><tr/>
<tr><td><strong>068.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429438/” target=”_blank” rel=”noopener”>Bacillus anthracis Edema Toxin Inhibits Efferocytosis in Human Macrophages and Alters Efferocytic Receptor Signaling</a><br/>Int J Mol Sci. 2019&emsp;&emsp;PMID:&nbsp;30866434</td><tr/>
<tr><td><strong>069.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/31219639/” target=” blank” rel=”noopener”>Cdc42 activation by endothelin regulates neural crest cell migration in the cardiac outflow tract</a><br/>Dev Dyn. 2019&emsp;&emsp;PMID:&nbsp; 31219639</td><tr/>
<tr><td><strong>070.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629836/” target=”_blank” rel=”noopener”>TUFT1 Promotes Triple Negative Breast Cancer Metastasis. Stemness. and Chemoresistance by Up-Regulating the Rac1/β-Catenin Pathway</a><br/>Front Oncol. 2019&emsp;&emsp;PMID:&nbsp;31338333</td><tr/>
<tr><td><strong>071.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/31410004/” target=”_blank” rel=”noopener”>Simvastatin pretreatment ameliorates t-PA–induced hemorrhage transformation and MMP-9/TIMP-1 imbalance in thromboembolic cerebral ischemic rats</a><br/>Neuropsychiatr Dis Treat. 2019&emsp;&emsp;PMID:&nbsp;31410004</td><tr/>
<tr><td><strong>072.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/31413255/” target=”_blank” rel=”noopener”>PTPσ inhibitors promote hematopoietic stem cell regeneration</a><br/>Nature Communications. 2019&emsp;&emsp;PMID:&nbsp;31413255</td><tr/>
<tr><td><strong>073.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/31529802/” target=” blank” rel=”noopener”>Quercetin Mitigates Hepatic Insulin Resistance in Rats with Bile Duct Ligation Through Modulation of the STAT3/SOCS3/IRS1 Signaling Pathway</a><br/>J Food Sci. 2019&emsp;&emsp;PMID:&nbsp;31529802</td><tr/>
<tr><td><strong>074.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757435/” target=”_blank” rel=”noopener”>TUFT1 promotes metastasis and chemoresistance in triple negative breast cancer through the TUFT1ab5ac1 pathway</a><br/>Cancer Cell Int. 2019&emsp;&emsp;PMID:&nbsp;31572059</td><tr/>
<tr><td><strong>075.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/31644919/” target=” blank” rel=”noopener”>Chemokine Receptor CCR7 Triggers an Endomembrane Signaling Complex for Spatial Rac Activation</a><br/>Cell Rep. 2019&emsp;&emsp;PMID:&nbsp;31644919</td><tr/>
<tr><td><strong>076.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876637/” target=” blank” rel=”noopener”>Interplay between …2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memory</a><br/>Nat Commun. 2019&emsp;&emsp;PMID:&nbsp;31757963</td><tr/>
<tr><td><strong>077.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/29155102/” target=” blank” rel=”noopener”>Targeting of Rac1 prevents bronchoconstriction and airway hyperresponsiveness</a><br/>J Allergy Clin Immunol. 2018&emsp;&emsp;PMID:&nbsp;29155102</td><tr/>
<tr><td><strong>078.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865965″ target=”_blank” rel=”noopener”>COL1A1 promotes metastasis in colorectal cancer by regulating the WNT/PCP pathway</a><br/>Mol Med Rep. 2018&emsp;&emsp;PMID:&nbsp;29393423</td><tr/>
<tr><td><strong>079.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/29444209/” target=” blank” rel=”noopener”>Geranylgeranyl pyrophosphate synthase facilitates the organization of cardiomyocytes during mid-gestation through modulating protein geranylgeranylation in mouse heart</a><br/>Cardiovasc Res. 2018&emsp;&emsp;PMID:&nbsp;29444209</td><tr/>
<tr><td><strong>080.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882563/” target=”_blank” rel=”noopener”>p66Shc Regulates Migration of Castration-Resistant Prostate Cancer Cells</a><br/>Cell Signal. 2018&emsp;&emsp;PMID:&nbsp;29462661</td><tr/>
<tr><td><strong>081.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832796″ target=”_blank” rel=”noopener”>Podocyte-specific Rac1 deficiency ameliorates podocyte damage and proteinuria in STZ-induced diabetic nephropathy in mice</a><br/>Cell Death Dis. 2018&emsp;&emsp;PMID:&nbsp;29497040</td><tr/>
<tr><td><strong>082.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916337/” target=”_blank” rel=”noopener”>Protein tyrosine kinase 7 regulates extracellular matrix integrity and mesenchymal intracellular RAC1 and myosin II activities during Wolffian duct morphogenesis</a><br/>Dev Biol. 2018 &emsp;&emsp;PMID:&nbsp;29580943</td><tr/>
<tr><td><strong>083.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/29581176/” target=” blank” rel=”noopener”>Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth</a><br/>Cancer Discov. 2018&emsp;&emsp;PMID:&nbsp;29581176</td><tr/>
<tr><td><strong>084.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949353/” target=”_blank” rel=”noopener”>Complement C3 Affects Rac1 Activity in the Developing Brain</a><br/>Front Mol Neurosci. 2018&emsp;&emsp;PMID:&nbsp;29867343</td><tr/>
<tr><td><strong>085.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/29875261/” target=” blank” rel=”noopener”>The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8 + T cells</a><br/>J Exp Med. 2018&emsp;&emsp;PMID:&nbsp;29875261</td><tr/>
<tr><td><strong>086.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/29884911/” target=”_blank” rel=”noopener”>RAC1-GTP promotes epithelial-mesenchymal transition and invasion of colorectal cancer by activation of STAT3</a><br/>Laboratory Investigation. 2018&emsp;&emsp;PMID:&nbsp;29884911</td><tr/>
<tr><td><strong>087.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037484/” target=”_blank” rel=”noopener”>Removing physiological motion from intravital and clinical functional imaging data</a><br/>eLife. 2018&emsp;&emsp;PMID:&nbsp;29985127</td><tr/>
<tr><td><strong>088.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/30005699/” target=”_blank” rel=”noopener”>Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer’s disease</a><br/>Acta Neuropathol Commun. 2018&emsp;&emsp;PMID:&nbsp;30005699</td><tr/>
<tr><td><strong>089.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036455/” target=”_blank” rel=”noopener”>MicroRNA-650 targets inhibitor of growth 4 to promote colorectal cancer progression via mitogen activated protein kinase signaling</a><br/>Oncol Lett. 2018 &emsp;&emsp;PMID:&nbsp;30008936</td><tr/>
<tr><td><strong>090.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329911/” target=”_blank” rel=”noopener”>The tetraspanin CD82 regulates bone marrow homing and engraftment of hematopoietic stem and progenitor cells</a><br/>Mol Biol Cell. 2018 &emsp;&emsp;PMID:&nbsp;30133344</td><tr/>
<tr><td><strong>091.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/27669437/” target=”_blank” rel=”noopener”>The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion</a><br/>Oncogene. 2017&emsp;&emsp;PMID:&nbsp;27669437</td><tr/>
<tr><td><strong>092.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/27927890/” target=” blank” rel=”noopener”>Massively Increased Caries Susceptibility in an Irf6 Cleft Lip/Palate Model</a><br/>J Dent Res. 2017&emsp;&emsp;PMID:&nbsp;27927890</td><tr/>
<tr><td><strong>093.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224981″ target=”_blank” rel=”noopener”>GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary</a><br/>PLoS Genet. 2017&emsp;&emsp;PMID:&nbsp;28072828</td><tr/>
<tr><td><strong>094.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410264/” target=”_blank” rel=”noopener”>Biological basis and clinical study of glycogen synthase kinase- 3β-targeted therapy by drug repositioning for glioblastoma</a><br/>Oncotarget. 2017&emsp;&emsp;PMID:&nbsp;28423558</td><tr/>
<tr><td><strong>095.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/28483380/” target=” blank” rel=”noopener”>Rac1 activation in podocytes induces the spectrum of nephrotic syndrome</a><br/>Kidney Int. 2017&emsp;&emsp;PMID:&nbsp;28483380</td><tr/>
<tr><td><strong>096.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/28552735/” target=”_blank” rel=”noopener”>N-cadherin regulates signaling mechanisms required for lens fiber cell elongation and lens morphogenesis</a><br/>Dev Biol. 2017&emsp;&emsp;PMID:&nbsp;28552735</td><tr/>
<tr><td><strong>097.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479300″ target=”_blank” rel=”noopener”>High glucose levels promote the proliferation of breast cancer cells through GTPases</a><br/>Breast Cancer (Dove Med Press). 2017&emsp;&emsp;PMID:&nbsp;28670141</td><tr/>
<tr><td><strong>098.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645739″ target=”_blank” rel=”noopener”>Role of Nicotinamide N-Methyltransferase in Dorsal Striatum in Cocaine Place Preference</a><br/>Neuropsychopharmacology. 2017&emsp;&emsp;PMID:&nbsp;28726800</td><tr/>
<tr><td><strong>099.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/28743719/” target=” blank” rel=”noopener”>The atypical receptor CCRL2 is required for CXCR2-dependent neutrophil recruitment and tissue damage</a><br/>Blood. 2017&emsp;&emsp;PMID:&nbsp;28743719</td><tr/>
<tr><td><strong>100.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/29016860/” target=” blank” rel=”noopener”>Primary angle closure glaucoma (PACG) susceptibility gene PLEKHA7 encodes a novel Rac1/Cdc42 GAP that modulates cell migration and blood-aqueous barrier function</a><br/>Hum Mol Genet. 2017&emsp;&emsp;PMID:&nbsp;29016860</td><tr/>
<tr><td><strong>101.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690821/” target=”_blank” rel=”noopener”>Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2</a><br/>Nature Immunology. 2017&emsp;&emsp;PMID:&nbsp;29058702</td><tr/>
<tr><td><strong>102.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689647/” target=” blank” rel=”noopener”>A PTEN-COL17A1 fusion gene and its novel regulatory role in Collagen XVII expression and GBM malignance</a><br/>Oncotarget. 2017&emsp;&emsp;PMID:&nbsp;29156757</td><tr/>
<tr><td><strong>103.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/29271742/” target=”_blank” rel=”noopener”>Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery</a><br/>eLife. 2017&emsp;&emsp;PMID:&nbsp;29271742</td><tr/>
<tr><td><strong>104.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905261″ target=”_blank” rel=”noopener”>Disease-causing mutations of RhoGDIa induce Rac1 hyperactivation in podocytes</a><br/>Small GTPases. 2016&emsp;&emsp;PMID:&nbsp;26726844</td><tr/>
<tr><td><strong>105.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/26775215/” target=” blank” rel=”noopener”>The acetylenic tricyclic bis(cyano enone). TBE-31. targets microtubule dynamics and cell polarity in migrating cells</a><br/>Biochim Biophys Acta. 2016&emsp;&emsp;PMID:&nbsp;26775215</td><tr/>
<tr><td><strong>106.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835924″ target=”_blank” rel=”noopener”>Dosage-dependent role of Rac1 in podocyte injury</a><br/>Am J Physiol Renal Physiol. 2016&emsp;&emsp;PMID:&nbsp;26792065</td><tr/>
<tr><td><strong>107.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/27008403/” target=”_blank” rel=”noopener”>Rac1/β-Catenin Signalling Pathway Contributes to Trophoblast Cell Invasion by Targeting Snail and MMP9.</a><br/>Cell Physiol Biochem. 2016 &emsp;&emsp;PMID:&nbsp;27008403</td><tr/>
<tr><td><strong>108.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004713″ target=”_blank” rel=”noopener”>A Stromal Cell–Derived Factor 1a Analogue Improves Endothelial Cell Function in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome</a><br/>Mol Med. 2016&emsp;&emsp;PMID:&nbsp;27031787</td><tr/>
<tr><td><strong>109.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/27130700/” target=” blank” rel=”noopener”>The RacGAP protein FilGAP is a negative regulator of chemokine-promoted lymphocyte migration</a><br/>FEBS Lett. 2016&emsp;&emsp;PMID:&nbsp; 27130700</td><tr/>
<tr><td><strong>110.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/27188212/” target=” blank” rel=”noopener”>Opposing effects of actin signaling and LFA-1 on establishing the affinity threshold for inducing effector T-cell responses in mice</a><br/>Eur J Immunol. 2016&emsp;&emsp;PMID:&nbsp; 27188212</td><tr/>
<tr><td><strong>111.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/27329554/” target=”_blank” rel=”noopener”>Inhibition of Rac1 activity in the hippocampus impaired extinction of contextual fear.</a><br/>Neuropharmacology. 2016 &emsp;&emsp;PMID:&nbsp;27329554</td><tr/>
<tr><td><strong>112.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/27330411/” target=”_blank” rel=”noopener”>Zinc induces epithelial to mesenchymal transition in human lung cancer H460 cells via superoxide anion-dependent mechanism</a><br/>Cancer Cell Int. 2016&emsp;&emsp;PMID:&nbsp;27330411</td><tr/>
<tr><td><strong>113.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/27425596/” target=”_blank” rel=”noopener”>RAC-LATS1/2 signaling regulates YAP activity by switching between the YAP-binding partners TEAD4 and RUNX3</a><br/>Oncogene. 2016 &emsp;&emsp;PMID:&nbsp;27425596</td><tr/>
<tr><td><strong>114.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/27452812/” target=”_blank” rel=”noopener”> Dietary flavonoid luteolin attenuates uropathogenic Escherichia. Coli invasion of the urinary bladder.</a><br/>Biofactors. 2016&emsp;&emsp;PMID:&nbsp;27452812</td><tr/>
<tr><td><strong>115.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/27469030/” target=”_blank” rel=”noopener”>Sur8 mediates tumorigenesis and metastasis in colorectal cancer</a><br/>Exp Mol Med. 2016&emsp;&emsp;PMID:&nbsp;27469030</td><tr/>
<tr><td><strong>116.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/27534887/” target=”_blank” rel=”noopener”>The modulation of MiR-155 and MiR-23a manipulates Klebsiella pneumoniae Adhesion on Human pulmonary Epithelial cells via Integrin α5β1 Signaling</a><br/>Sci Rep. 2016&emsp;&emsp;PMID:&nbsp;27534887</td><tr/>
<tr><td><strong>117.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019934″ target=”_blank” rel=”noopener”>Gigantol Inhibits Epithelial to Mesenchymal Process in Human Lung Cancer Cells</a><br/>Evid Based Complement Alternat Med. 2016&emsp;&emsp;PMID:&nbsp;27651818</td><tr/>
<tr><td><strong>118.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206404/” target=”_blank” rel=”noopener”>Rac1 modulates mammalian lung branching morphogenesis in part through canonical Wnt signaling</a><br/>Am J Physiol Lung Cell Mol Physiol. 2016 &emsp;&emsp;PMID:&nbsp;27765763</td><tr/>
<tr><td><strong>119.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/27807170/” target=”_blank” rel=”noopener”>Converging. Synergistic Actions of Multiple Stress Hormones Mediate Enduring Memory Impairments after Acute Simultaneous Stresses</a><br/>J Neurosci. 2016&emsp;&emsp;PMID:&nbsp;27807170</td><tr/>
<tr><td><strong>120.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/27999173/” target=” blank” rel=”noopener”>Rac signal adaptation controls neutrophil mobilization from the bone marrow</a><br/>Sci Signal. 2016 &emsp;&emsp;PMID:&nbsp;27999173</td><tr/>
<tr><td><strong>121.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/25209090/” target=” blank” rel=”noopener”>miRNA-17 members that target Bmpr2 influence signaling mechanisms important for embryonic stem cell differentiation in vitro and gastrulation in embryos</a><br/>Stem Cells Dev. 2015&emsp;&emsp;PMID:&nbsp;25209090</td><tr/>
<tr><td><strong>122.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821470/” target=”_blank” rel=”noopener”>LPA-mediated migration of ovarian cancer cells involves translocalization of Gαi2 to invadopodia and association with Src and β-pix</a><br/>Cancer Lett. 2015&emsp;&emsp;PMID:&nbsp;25451317</td><tr/>
<tr><td><strong>123.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/25529012/” target=”_blank” rel=”noopener”>Semaphorin-3F suppresses the stemness of colorectal cancer cells by inactivating Rac1</a><br/>Cancer letters. 2015&emsp;&emsp;PMID:&nbsp;25529012</td><tr/>
<tr><td><strong>124.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/25595279/” target=”_blank” rel=”noopener”>Rac1/Pak1/p38/MMP-2 axis regulates angiogenesis in ovarian cancer</a><br/>Clin Cancer Res. 2015&emsp;&emsp;PMID:&nbsp;25595279</td><tr/>
<tr><td><strong>125.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/25613020/” target=”_blank” rel=”noopener”>Inhibition of Rac1 Activity in the Hippocampus Impairs the Forgetting of Contextual Fear Memory</a><br/>Mol Neurobiol. 2015&emsp;&emsp;PMID:&nbsp;25613020</td><tr/>
<tr><td><strong>126.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/25666619/” target=”_blank” rel=”noopener”>Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase</a><br/>J Biol Chem. 2015&emsp;&emsp;PMID:&nbsp;25666619</td><tr/>
<tr><td><strong>127.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/25874856/” target=”_blank” rel=”noopener”>Fibroblastic Transformation of Corneal Keratocytes by Rac Inhibition is Modulated by Extracellular Matrix Structure and Stiffness</a><br/>J Funct Biomater. 2015&emsp;&emsp;PMID:&nbsp;25874856</td><tr/>
<tr><td><strong>128.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387585″ target=”_blank” rel=”noopener”>Qian Yang Yu Yin Granule-containing serum inhibits angiotensin II-induced proliferation. reactive oxygen species production. and inflammation in human mesangial cells via an NADPH oxidase 4-dependent pathway</a><br/>BMC Complement Altern Med. 2015&emsp;&emsp;PMID:&nbsp;25886843</td><tr/>
<tr><td><strong>129.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/25912734/” target=”_blank” rel=”noopener”>TIPE2 protein prevents injury-induced restenosis in mice</a><br/>Biochim Biophys Acta. 2015&emsp;&emsp;PMID:&nbsp;25912734</td><tr/>
<tr><td><strong>130.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/25957559/” target=”_blank” rel=”noopener”>Dishevelled-2 regulates cocaine-induced structural plasticity and Rac1 activity in the nucleus accumbens</a><br/>Neurosci Lett. 2015&emsp;&emsp;PMID:&nbsp;25957559</td><tr/>
<tr><td><strong>131.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/26109451/” target=” blank” rel=”noopener”>A bibenzyl from Dendrobium ellipsophyllum inhibits migration in lung cancer cells</a><br/>J Nat Med. 2015&emsp;&emsp;PMID:&nbsp;26109451</td><tr/>
<tr><td><strong>132.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522160″ target=”_blank” rel=”noopener”>The cytohesin guanosine exchange factors (GEFs) are required to promote HGF-mediated renal recovery after acute kidney injury (AKI) in mice</a><br/>Physiol Rep. 2015&emsp;&emsp;PMID:&nbsp;26116550</td><tr/>
<tr><td><strong>133.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510974/” target=” blank” rel=”noopener”>A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration</a><br/>Nat Commun. 2015&emsp;&emsp;PMID:&nbsp;26166433</td><tr/>
<tr><td><strong>134.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/26184908/” target=”_blank” rel=”noopener”>Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice</a><br/>Cell Death Differ. 2015&emsp;&emsp;PMID:&nbsp;26184908</td><tr/>
<tr><td><strong>135.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526116/” target=” blank” rel=”noopener”>Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers</a><br/>Nat Commun. 2015&emsp;&emsp;PMID:&nbsp;26234763</td><tr/>
<tr><td><strong>136.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/26299339/” target=”_blank” rel=”noopener”>Rac1 contributes to cerebral ischemia reperfusion-induced injury in mice by regulation of Notch2</a><br/>Neuroscience. 2015.&emsp;&emsp;PMID:&nbsp;26299339</td><tr/>
<tr><td><strong>137.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549291/” target=” blank” rel=”noopener”>Rac1 Regulates Endometrial Secretory Function to Control Placental Development</a><br/>PLoS Genet. 2015&emsp;&emsp;PMID:&nbsp;26305333</td><tr/>
<tr><td><strong>138.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741751″ target=”_blank” rel=”noopener”>Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling</a><br/>Oncotarget. 2015&emsp;&emsp;PMID:&nbsp;26384305</td><tr/>
<tr><td><strong>139.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657330/” target=”_blank” rel=”noopener”>Rac1 augments Wnt signaling by stimulating beta-catenin-LEF-1 complex assembly independent of beta-catenin nuclear import</a><br/>J Cell Sci. 2015&emsp;&emsp;PMID:&nbsp;26403202</td><tr/>
<tr><td><strong>140.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729241/” target=” blank” rel=”noopener”>Rap1 GTPase Inhibits Tumor Necrosis Factor-à-Induced Choroidal Endothelial Migration via NADPH Oxidase- and NF-?B-Dependent Activation of Rac1</a><br/>Am J Pathol. 2015&emsp;&emsp;PMID:&nbsp;26476350</td><tr/>
<tr><td><strong>141.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/26725196/” target=”_blank” rel=”noopener”>Cyclic Mechanical Loading Is Essential for Rac1-Mediated Elongation and Remodeling of the Embryonic Mitral Valve</a><br/>Current Biology. 2015&emsp;&emsp;PMID:&nbsp;26725196</td><tr/>
<tr><td><strong>142.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/18453118/” target=”_blank” rel=”noopener”>Immunofluorescence and Confocal Microscopy of Neutrophils</a><br/>Methods Mol Biol. 2014&emsp;&emsp;PMID:&nbsp;18453118</td><tr/>
<tr><td><strong>143.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/24498424/” target=”_blank” rel=”noopener”>Jak3 Enables Chemokine-Dependent Actin Cytoskeleton Reorganization by Regulating Cofilin and Rac/Rhoa GTPases activation</a><br/>PLoS One. 2014&emsp;&emsp;PMID:&nbsp;24498424</td><tr/>
<tr><td><strong>144.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/24531394/” target=” blank” rel=”noopener”>High incidence of naevi-associated BRAF wild-type melanoma and dysplastic naevi under treatment with the class I BRAF inhibitor vemurafenib</a><br/>Acta Derm Venereol. 2014&emsp;&emsp;PMID:&nbsp;24531394</td><tr/>
<tr><td><strong>145.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/24561795/” target=”_blank” rel=”noopener”>A link between the nuclear-localized srGAP3 and the SWI/SNF chromatin remodeler Brg1</a><br/>Molecular and Cellular Neuroscience. 2014&emsp;&emsp;PMID:&nbsp;24561795</td><tr/>
<tr><td><strong>146.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/24574051/” target=”_blank” rel=”noopener”>Phosphorylation of α-tubulin by protein kinase C stimulates microtubule dynamics in human breast cells</a><br/>Cytoskeleton. 2014&emsp;&emsp;PMID:&nbsp;24574051</td><tr/>
<tr><td><strong>147.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383135/” target=”_blank” rel=”noopener”>SHP2 Phosphatase Promotes Mast Cell Chemotaxis toward Stem Cell Factor via Enhancing Activation of the Lyn/Vavac Signaling Axis</a><br/>The Journal of Immunology. 2014&emsp;&emsp;PMID:&nbsp;24733849</td><tr/>
<tr><td><strong>148.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/24752651/” target=”_blank” rel=”noopener”>ROBO1. a tumor suppressor and critical molecular barrier for localized tumor cells to acquire invasive phenotype: Study in African-American and Caucasian prostate cancer models</a><br/>International Journal of Cancer. 2014&emsp;&emsp;PMID:&nbsp;24752651</td><tr/>
<tr><td><strong>149.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/24759106/” target=”_blank” rel=”noopener”>Transcription factors NRF2 and nf-kb are coordinated effectors of the RHO family. GTP binding protein rac1 during inflammation</a><br/>J Biol Chem. 2014 &emsp;&emsp;PMID:&nbsp;24759106</td><tr/>
<tr><td><strong>150.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034421/” target=” blank” rel=”noopener”>PI(4.5)P2 regulates myoblast fusion through Arp2/3 regulator localization at the fusion site</a><br/>Development. 2014&emsp;&emsp;PMID:&nbsp;24821989</td><tr/>
<tr><td><strong>151.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/24859471/” target=” blank” rel=”noopener”>Loss of ARHGDIA expression is associated with poor prognosis in HCC and promotes invasion and metastasis of HCC cells</a><br/>Int J Oncol. 2014&emsp;&emsp;PMID:&nbsp;24859471</td><tr/>
<tr><td><strong>152.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/25149377/” target=” blank” rel=”noopener”>srGAP3 promotes neurite outgrowth of dorsal root ganglion neurons by inactivating RAC1</a><br/>Asian Pac J Trop Med. 2014&emsp;&emsp;PMID:&nbsp;25149377</td><tr/>
<tr><td><strong>153.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248717/” target=”_blank” rel=”noopener”>Canonical and Non-canonical G-protein Signaling Helps Coordinate Actin Dynamics to Promote Macrophage Phagocytosis of Zymosan</a><br/>Mol Cell Biol. 2014 &emsp;&emsp;PMID:&nbsp;25225330</td><tr/>
<tr><td><strong>154.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/25247424/” target=”_blank” rel=”noopener”>p53 Down Regulates PDGF-Induced Formation of Circular Dorsal Ruffles in Rat Aortic Smooth Muscle Cells</a><br/>PLoS One. 2014 &emsp;&emsp;PMID:&nbsp;25247424</td><tr/>
<tr><td><strong>155.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347231″ target=”_blank” rel=”noopener”>TRPM2 mediates ischemic kidney injury and oxidant stress through RAC1</a><br/>J Clin Invest. 2014&emsp;&emsp;PMID:&nbsp;25295536</td><tr/>
<tr><td><strong>156.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199721″ target=”_blank” rel=”noopener”>Triclosan Potentiates Epithelial-To-Mesenchymal Transition in Anoikis-Resistant Human Lung Cancer Cells</a><br/>PLoS One. 2014&emsp;&emsp;PMID:&nbsp;25329306</td><tr/>
<tr><td><strong>157.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254100/” target=”_blank” rel=”noopener”>cAMP controls the restoration of endothelial barrier function after thrombin‐induced hyperpermeability via Rac1 activation</a><br/>Physiological Reports. 2014&emsp;&emsp;PMID:&nbsp;25344477</td><tr/>
<tr><td><strong>158.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/25503138/” target=”_blank” rel=”noopener”>Cisplatin at Sub-toxic Levels Mediates Integrin Switch in Lung Cancer Cells</a><br/>Anticancer Research. 2014&emsp;&emsp;PMID:&nbsp;25503138</td><tr/>
<tr><td><strong>159.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/25539497/” target=”_blank” rel=”noopener”>Geometry sensing through POR1 regulates Rac1 activity controlling early osteoblast differentiation in response to nanofiber diameter</a><br/>Integr Biol (Camb). 2014&emsp;&emsp;PMID:&nbsp;25539497</td><tr/>
<tr><td><strong>160.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/23148218/” target=”_blank” rel=”noopener”>Neuregulin Mediates F-actin-driven Cell Migration through Inhibition of Protein Kinase D1 via Rac1 Protein</a><br/>J Biol Chem. 2013&emsp;&emsp;PMID:&nbsp;23148218</td><tr/>
<tr><td><strong>161.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/23153508/” target=”_blank” rel=”noopener”>Rac1/PAK1 signaling promotes epithelial-mesenchymal transition of podocytes in vitro via triggering beta-catenin transcriptional activity under high glucose conditions</a><br/>Int J Biochem Cell Biol. 2013 &emsp;&emsp;PMID:&nbsp;23153508</td><tr/>
<tr><td><strong>162.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/23175375/” target=”_blank” rel=”noopener”>Reactive Oxygen Species Are Induced by Kaposi’s Sarcoma-Associated Herpesvirus Early during Primary Infection of Endothelial Cells To Promote Virus Entry</a><br/>J Virol. 2013&emsp;&emsp;PMID:&nbsp;23175375</td><tr/>
<tr><td><strong>163.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/23192342/” target=”_blank” rel=”noopener”>Essential Role of Class II Phosphatidylinositol-3-kinase-C2alpha in Sphingosine 1-Phosphate Receptor-1-mediated Signaling and Migration in Endothelial Cells</a><br/>J Biol Chem. 2013&emsp;&emsp;PMID:&nbsp;23192342</td><tr/>
<tr><td><strong>164.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/23321640/s” target=”_blank” rel=”noopener”>PAK-PIX interactions regulate adhesion dynamics and membrane protrusion to control neurite outgrowt</a><br/>J Cell Sci. 2013&emsp;&emsp;PMID:&nbsp;23321640</td><tr/>
<tr><td><strong>165.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557251″ target=”_blank” rel=”noopener”>Deficiencies of the Lipid-Signaling Enzymes Phospholipase D1 and D2 Alter Cytoskeletal Organization. Macrophage Phagocytosis. and Cytokine-Stimulated Neutrophil Recruitment</a><br/>PLoS One. 2013&emsp;&emsp;PMID:&nbsp;23383154</td><tr/>
<tr><td><strong>166.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/23429587/” target=” blank” rel=”noopener”>Myocardial Rac1 exhibits partial involvement in thyroxin-induced cardiomyocyte hypertrophy and its inhibition is not sufficient to improve cardiac dysfunction or contractile abnormalities in mouse papillary muscles</a><br/>J Cardiovasc Pharmacol. 2013 &emsp;&emsp;PMID:&nbsp;23429587</td><tr/>
<tr><td><strong>167.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669177/” target=”_blank” rel=”noopener”>A chimerical phagocytosis model reveals the recruitment by Sertoli cells of autophagy for the degradation of ingested illegitimate substrates</a><br/>Autophagy. 2013&emsp;&emsp;PMID:&nbsp;23439251</td><tr/>
<tr><td><strong>168.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672376/” target=”_blank” rel=”noopener”>Rac1 is required for matrix metalloproteinase-13 production by chondrocytes in response to fibronectin fragments</a><br/>Arthritis Rheum. 2013&emsp;&emsp;PMID:&nbsp;23460186</td><tr/>
<tr><td><strong>169.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621493/” target=”_blank” rel=”noopener”>Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization</a><br/>Development. 2013&emsp;&emsp;PMID:&nbsp;23533177</td><tr/>
<tr><td><strong>170.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/23699534/” target=”_blank” rel=”noopener”>Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis</a><br/>Mol Cancer Res. 2013 &emsp;&emsp;PMID:&nbsp;23699534</td><tr/>
<tr><td><strong>171.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662692/” target=”_blank” rel=”noopener”>Pilus Phase Variation Switches Gonococcal Adherence to Invasion by Caveolin-1-Dependent Host Cell Signaling</a><br/>PLoS Pathog. 2013&emsp;&emsp;PMID:&nbsp;23717204</td><tr/>
<tr><td><strong>172.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774378/” target=”_blank” rel=”noopener”>ArhGAP15. a Rac-specific GTPase-activating Protein. Plays a Dual Role in Inhibiting Small GTPase Signaling</a><br/>J Biol Chem. 2013&emsp;&emsp;PMID:&nbsp;23760270</td><tr/>
<tr><td><strong>173.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718375/” target=”_blank” rel=”noopener”>Kalirin-7 Mediates Cocaine-Induced AMPA Receptor and Spine Plasticity. Enabling Incentive Sensitization</a><br/>J Neurosci. 2013&emsp;&emsp;PMID:&nbsp;23825406</td><tr/>
<tr><td><strong>174.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/24019894/” target=”_blank” rel=”noopener”>p21-Activated Kinase (PAK) Regulates Cytoskeletal Reorganization and Directional Migration in Human Neutrophils</a><br/>PLoS One. 2013&emsp;&emsp;PMID:&nbsp;24019894</td><tr/>
<tr><td><strong>175.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824649″ target=”_blank” rel=”noopener”>Loss of TAK1 increases cell traction force in a ROS-dependent manner to drive epithelial–mesenchymal transition of cancer cells</a><br/>Cell Death Dis. 2013&emsp;&emsp;PMID:&nbsp;24113182</td><tr/>
<tr><td><strong>176.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823815/” target=” blank” rel=”noopener”>A directional switch of integrin signaling and a new anti-thrombotic strategy</a><br/>Nature. 2013&emsp;&emsp;PMID:&nbsp;24162846</td><tr/>
<tr><td><strong>177.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/24368807/” target=” blank” rel=”noopener”>JAK tyrosine kinases promote hierarchical activation of Rho and Rap modules of integrin activation</a><br/>J Cell Biol. 2013&emsp;&emsp;PMID:&nbsp;24368807</td><tr/>
<tr><td><strong>178.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/21999233/” target=”_blank” rel=”noopener”>he cooperative action of bacterial fibronectin-binding proteins and secreted proteins promote maximal Campylobacter jejuni invasion of host cells by stimulating membrane ruffling</a><br/>Cell Microbiol. 2012 &emsp;&emsp;PMID:&nbsp;21999233</td><tr/>
<tr><td><strong>179.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/22137120/” target=”_blank” rel=”noopener”>Interferon gamma induces actin polymerization. Rac1 activation and down regulates phagocytosis in human monocytic cells</a><br/>Cytokine. 2012&emsp;&emsp;PMID:&nbsp;22137120</td><tr/>
<tr><td><strong>180.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/22203054/” target=” blank” rel=”noopener”>Co-regulation of transcellular and paracellular leak across microvascular endothelium by dynamin and Rac</a><br/>Am J Pathol. 2012&emsp;&emsp;PMID:&nbsp;22203054</td><tr/>
<tr><td><strong>181.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/22349701/” target=” blank” rel=”noopener”>Association of syntenin-1 with M-RIP polarizes Rac-1 activation during chemotaxis and immune interactions</a><br/>J Cell Sci. 2012&emsp;&emsp;PMID:&nbsp;22349701</td><tr/>
<tr><td><strong>182.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/22522400/” target=”_blank” rel=”noopener”>rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons</a><br/>Nat Neurosci. 2012&emsp;&emsp;PMID:&nbsp;22522400</td><tr/>
<tr><td><strong>183.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/22553120/” target=”_blank” rel=”noopener”>Antagonistic activities of Rho and Rac GTPases underlie the transition from neural crest delamination to migration</a><br/>Dev Dyn. 2012 &emsp;&emsp;PMID:&nbsp;22553120</td><tr/>
<tr><td><strong>184.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395090/” target=” blank” rel=”noopener”>miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling</a><br/>EMBO J. 2012&emsp;&emsp;PMID:&nbsp; 22588079</td><tr/>
<tr><td><strong>185.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/22623753/” target=”_blank” rel=”noopener”>Interferon-beta Therapy Against EAE Is Effective Only When Development of the Disease Depends on the NLRP3 Inflammasome</a><br/>Sci Signal. 2012&emsp;&emsp;PMID:&nbsp;22623753</td><tr/>
<tr><td><strong>186.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/22695959/” target=”_blank” rel=”noopener”>Rac1 inhibition prevents tissue contraction and MMP mediated matrix remodeling in the conjunctiva</a><br/>Invest Ophthalmol Vis Sci. 2012 &emsp;&emsp;PMID:&nbsp;22695959</td><tr/>
<tr><td><strong>187.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514035″ target=”_blank” rel=”noopener”>Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex</a><br/>J Cell Biol. 2012&emsp;&emsp;PMID:&nbsp;22891260</td><tr/>
<tr><td><strong>188.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/22936985/” target=”_blank” rel=”noopener”>Rac-induced left ventricular dilation in thyroxin-treated ZmRacD transgenic mice: role of cardiomyocyte apoptosis and myocardial fibrosis</a><br/>PLoS One. 2012&emsp;&emsp;PMID:&nbsp;22936985</td><tr/>
<tr><td><strong>189.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/23185572/” target=”_blank” rel=”noopener”>Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion</a><br/>PLoS One. 2012&emsp;&emsp;PMID:&nbsp;23185572</td><tr/>
<tr><td><strong>190.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/23197717/” target=”_blank” rel=”noopener”>Rac1 controls Schwann cell myelination through cAMP and NF2/merlin </a><br/>J Neurosci. 2012&emsp;&emsp;PMID:&nbsp;23197717</td><tr/>
<tr><td><strong>191.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/23223289/” target=”_blank” rel=”noopener”>Nerve growth factor-induced formation of axonal filopodia and collateral branches involves the intra-axonal synthesis of regulators of the actin-nucleating Arp2/3 complex</a><br/>J Neurosci. 2012&emsp;&emsp;PMID:&nbsp;23223289</td><tr/>
<tr><td><strong>192.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/21037229/” target=”_blank” rel=”noopener”>Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activation</a><br/>Am J Physiol Heart Circ Physiol. 2011 &emsp;&emsp;PMID:&nbsp;21037229</td><tr/>
<tr><td><strong>193.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/21358804/” target=”_blank” rel=”noopener”>K-Ras mediated murine epidermal tumorigenesis is dependent upon and associated with elevated Rac1 activity</a><br/>PLoS One. 2011&emsp;&emsp;PMID:&nbsp;21358804</td><tr/>
<tr><td><strong>194.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062424/” target=” blank” rel=”noopener”>Asymmetric Mbc. active Rac1 and F-actin foci in the fusion-competent myoblasts during myoblast fusion in Drosophila</a><br/>Development. 2011&emsp;&emsp;PMID:&nbsp;21389053</td><tr/>
<tr><td><strong>195.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/21563770/” target=”_blank” rel=”noopener”>Aspect ratio determines the quantity of mesoporous silica nanoparticle uptake by a small GTPase-dependent macropinocytosis mechanism</a><br/>ACS Nano. 2011&emsp;&emsp;PMID:&nbsp;21563770</td><tr/>
<tr><td><strong>196.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129188″ target=”_blank” rel=”noopener”>R-Ras and Rac GTPase Cross-talk Regulates Hematopoietic Progenitor Cell Migration. Homing. and Mobilization</a><br/>J Biol Chem. 2011&emsp;&emsp;PMID:&nbsp;21572048</td><tr/>
<tr><td><strong>197.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/21624123/” target=”_blank” rel=”noopener”>Differential roles of Smad2 and Smad3 in the regulation of TGF-beta1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1</a><br/>Mol Cancer. 2011&emsp;&emsp;PMID:&nbsp;21624123</td><tr/>
<tr><td><strong>198.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/21859816/” target=”_blank” rel=”noopener”>NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1</a><br/>Cardiovasc Res. 2011&emsp;&emsp;PMID:&nbsp;21859816</td><tr/>
<tr><td><strong>199.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/21881052/” target=”_blank” rel=”noopener”>Latent KSHV infection increases the vascular permeability of human endothelial cells</a><br/>Blood. 2011 &emsp;&emsp;PMID:&nbsp;21881052</td><tr/>
<tr><td><strong>200.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/21893601/” target=”_blank” rel=”noopener”>Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype</a><br/>J Cell Biol. 2011&emsp;&emsp;PMID:&nbsp;21893601</td><tr/>
<tr><td><strong>201.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/21961005/” target=”_blank” rel=”noopener”>Rac1 and Stathmin but Not EB1 Are Required for Invasion of Breast Cancer Cells in Response to IGF-I</a><br/>Int J Cell Biol. 2011&emsp;&emsp;PMID:&nbsp;21961005</td><tr/>
<tr><td><strong>202.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/21985251/” target=” blank” rel=”noopener”>Ethanol increases p190RhoGAP activity. leading to actin cytoskeleton rearrangements</a><br/>J Neurochem. 2011&emsp;&emsp;PMID:&nbsp;21985251</td><tr/>
<tr><td><strong>203.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/20610796/” target=”_blank” rel=”noopener”>Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis</a><br/>J Leukoc Biol. 2010&emsp;&emsp;PMID:&nbsp;20610796</td><tr/>
<tr><td><strong>204.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/20621840/” target=”_blank” rel=”noopener”>Intracellular Ca2+ can compensate for the lack of NADPH oxidase-derived ROS in endothelial cells</a><br/>FEBS Lett. 2010&emsp;&emsp;PMID:&nbsp;20621840</td><tr/>
<tr><td><strong>205.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/20636139/” target=”_blank” rel=”noopener”>Antioxidants counteract nicotine and promote migration via RacGTP in oral fibroblast cells</a><br/>J Periodontol. 2010&emsp;&emsp;PMID:&nbsp;20636139</td><tr/>
<tr><td><strong>206.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/20720104/” target=”_blank” rel=”noopener”>Physiological activation of synaptic Rac&gt;PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome</a><br/>J Neurosci. 2010&emsp;&emsp;PMID:&nbsp;20720104</td><tr/>
<tr><td><strong>207.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/20935639/” target=”_blank” rel=”noopener”>SUMOylation of the GTPase Rac1 is required for optimal cell migration</a><br/>Nat Cell Biol. 2010&emsp;&emsp;PMID:&nbsp;20935639</td><tr/>
</tbody>
</table>