| 货号: 12202 |
| 产品全名: Mouse TREM2 蛋白 |
| 规格: 10/50/100 µg |
| 基因符号 TREM-2;Trem2a;Trem2b;Trem2c |
| 目标蛋白: TREM2 |
| UNIPROT ID: Q99NH8 |
| 描述: Recombinant mouse TREM2 protein with C-terminal human Fc tag |
| 背景: The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013] |
| 物种/宿主: HEK293 |
| 分子量: The protein has a predicted molecular mass of 42.9 kDa after removal of the signal peptide. |
| 分子特征: Mouse TREM2(Leu19-Ser171) hFc(Glu99-Ala330) |
| 纯化: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. |
| 储存和运输: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Figure 1. Mouse TREM2 Protein, hFc Tag on SDS-PAGE under reducing condition. |
