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Human SCUBE2(441-659) Protein

Recombinant human SCUBE2(441-659) protein with C-terminal human Fc tag
5/5

$479.00

货号:12287

规格: 100 μg

库存状态:In Stock

           产品描述          
货号:   12287
产品全名:   人 SCUBE2(441-659) 蛋白
规格:   10/50/100 µg
基因符号   CEGP1;Scube/You
目标蛋白:    SCUBE2
UNIPROT ID:    Q9NQ36
描述:   Recombinant human SCUBE2(441-659) protein with C-terminal human Fc tag
背景:     Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22902404, PubMed:22677548). Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195). Synergizes with DISP1 to increase SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687).[UniProtKB/Swiss-Prot Function]
物种/宿主:    HEK293
分子量:   The protein has a predicted molecular mass of 50.2 kDa after removal of the signal peptide. The apparent molecular mass of SCUBE2(441-659)-hFc is approximately 35-55 kDa due to glycosylation.
分子特征:   SCUBE2(Asp441-Asn659 ) hFc(Glu99-Ala330)
纯化:   The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:   Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
储存和运输:   Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human SCUBE2 (441-659) Protein, hFc Tag on SDS-PAGE under reducing condition.
           引用文献