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Human NOTCH3 Protein, hFc Tag

Recombinant human NOTCH3 protein with C-terminal human Fc tag
5/5

$479.00

货号:11442

规格: 100 μg

库存状态:In Stock

           产品描述          
货号:   11442
产品全名:   人 NOTCH3 蛋白
规格:   10/50/100 µg
基因符号   CADASIL;CADASIL1;CASIL;IMF2;LMNS
目标蛋白:    NOTCH3
UNIPROT ID:    Q9UM47
描述:   Recombinant human NOTCH3 protein with C-terminal human Fc tag
背景:     This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]
物种/宿主:    HEK293
分子量:   The protein has a predicted molecular mass of 70.9 kDa after removal of the signal peptide. The apparent molecular mass of NOTCH3-hFc is approximately 70-100 kDa due to glycosylation.
分子特征:   NOTCH3(Ala40-Glu467) hFc(Glu99-Ala330)
纯化:   The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:   Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
储存和运输:   Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human NOTCH3 Protein, His Tag on SDS-PAGE under reducing condition.
           引用文献