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Human GHR Protein, hFc Tag

Recombinant Human GHR with C-terminal human Fc tag
5/5

$389.00

货号:11434

规格: 100 μg

库存状态:In Stock

           产品描述          
货号:   11434
产品全名:   人 GHR 蛋白
规格:   10/50/100 µg
基因符号   GHBP;GHIP
目标蛋白:    GHR
UNIPROT ID:    P10912
描述:   Recombinant Human GHR with C-terminal human Fc tag
背景:     This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
物种/宿主:    HEK293
分子量:   The protein has a predicted molecular mass of 53.8 kDa after removal of the signal peptide. The apparent molecular mass of GHR-hFc is approximately 55-100 kDa due to glycosylation.
分子特征:   GHR(Ala27-Thr264) hFc(Glu99-Ala330)
纯化:   The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:   Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
储存和运输:   Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human GHR Protein, hFc Tag on SDS-PAGE under reducing condition.
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