武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

微信:Neweast Biosciences

咨询:027 – 63497286 

Human GDNF Protein, hFc Tag

Recombinant Human GDNF with C-terminal human Fc tag
5/5

$479.00

货号:11645

规格: 100 μg

库存状态:In Stock

           产品描述          
货号:   11645
产品全名:   人 GDNF 蛋白
规格:   10/50/100 µg
基因符号   ATF;ATF1;ATF2;HFB1-GDNF;HSCR3
目标蛋白:    GDNF
UNIPROT ID:    P39905
描述:   Recombinant Human GDNF with C-terminal human Fc tag
背景:     This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
物种/宿主:    HEK293
分子量:   The protein has a predicted molecular mass of 41.2 kDa after removal of the signal peptide. The apparent molecular mass of GDNF-hFc is approximately 55-70 kDa due to glycosylation.
分子特征:   GDNF(Ser78-Ile211) hFc(Glu99-Ala330)
纯化:   The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:   Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
储存和运输:   Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human FOLR2 Protein, hFc Tag on SDS-PAGE under reducing condition.
           引用文献