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Human ADORA2A Protein, hFc Tag

Recombinant human ADORA2A Protein with C-terminal Human Fc tag
5/5

$389.00

货号:11234

规格: 100 μg

库存状态:In Stock

           产品描述          
货号:   11234
产品全名:   人 ADORA2A 蛋白
规格:   10/50/100 µg
基因符号   A2aR;ADORA2;RDC8
目标蛋白:    ADORA2A
UNIPROT ID:    P29274
描述:   Recombinant human ADORA2A Protein with C-terminal Human Fc tag
背景:     This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
物种/宿主:    HEK293
分子量:   The protein has a predicted molecular mass of 31.7 kDa after removal of the signal peptide.The apparent molecular mass of ADORA2A-hFc is approximately 35-55 kDa due to glycosylation.
分子特征:   ADORA2A(Met1-Ser7) (Ser67-His77) (Asn144-Pro173) (Cys259-Pro266) hFc(Glu99-Ala330)
纯化:   The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:   Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
储存和运输:   Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human ADORA2A Protein, hFc Tag on SDS-PAGE under reducing condition.
           引用文献