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GDNF (DMC498) IgG1 Chimeric mAb

Anti-GDNF (DMC498) IgG1 Chimeric Monoclonal Antibody
5/5

¥445.00

货号:28271

规格: 100 μg

库存状态:In Stock

           产品描述          
货号:   28271
产品全名:   GDNF(DMC498) IgG1 Chimeric 单抗
基因符号   ATF; ATF1; ATF2; HFB1-GDNF; HSCR3
描述:   GDNF antibody(DMC498) IgG1 Chimeric 单抗
背景:   This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein; a highly conserved neurotrophic factor; was shown to promote the survival and differentiation of dopaminergic neurons in culture; and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq; Aug 2016]
经过测试的应用:   Flow Cyt
推荐稀释比:   Flow Cyt 1:100
种属反应性:   Rabbit
亚型:   Rabbit:Human Fc chimeric IgG1
纯化:   Purified from cell culture supernatant by affinity chromatography
种属反应性:   人 GDNF
成分:   Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
储存和运输:   Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. Flow cytometry analysis with Anti-GDNF (DMC498) on Expi293 cells transfected with human GDNF (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
           引用文献