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CDH1 (DMC484) IgG1 Chimeric mAb

Anti-CDH1 (DMC484) IgG1 Chimeric Monoclonal Antibody
5/5

¥445.00

货号:28260

规格: 100 μg

库存状态:In Stock

           产品描述          
货号:   28260
产品全名:   CDH1(DMC484) IgG1 Chimeric 单抗
基因符号   Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO
描述:   CDH1 antibody(DMC484) IgG1 Chimeric 单抗
背景:   This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants; at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats; a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric; breast; colorectal; thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation; invasion; and:or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq; Nov 2015]
经过测试的应用:   Flow Cyt
推荐稀释比:   Flow Cyt 1:100
种属反应性:   Rabbit
亚型:   Rabbit:Human Fc chimeric IgG1
纯化:   Purified from cell culture supernatant by affinity chromatography
种属反应性:   人 CDH1
成分:   Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
储存和运输:   Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. Flow cytometry analysis with Anti-CDH1 (DMC484) on Expi293 cells transfected with human CDH1 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
           引用文献