武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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TJP1 Rabbit pAb

Anti-TJP1 Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S222284

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S222284
产品全名:   TJP1 兔多抗
基因符号   ZO-1
UNIPROT ID:   Q07157 (Gene Accession – NP_003248 )
背景:   This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms.
抗原:   Synthetic peptide of human TJP1
经过测试的应用:   ELISA, IHC
推荐稀释比:   IHC: 50-100; ELISA: 5000-10000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human, Mouse, Rat
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Signal Transduction
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 222284(TJP1 Antibody) at a dilution of 1/50(Cytoplasm and Cell membrane).

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the synthetic peptide and then with 222284(Anti-TJP1 Antibody) at dilution 1/50.
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