武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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TAB1 Rabbit pAb

Anti-TAB1 Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S217589

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S217589
产品全名:   TAB1 兔多抗
基因符号   3′-Tab1; MAP3K7IP1
UNIPROT ID:   Q15750 (Gene Accession – BC050554 )
背景:   The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
抗原:   Fusion protein of human TAB1
经过测试的应用:   ELISA, IHC
推荐稀释比:   IHC: 50-100; ELISA: 5000-10000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human, Mouse
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Signal Transduction, Cardiovascular, Immunology
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human colorectal cancer tissue using 217589(TAB1 Antibody) at a dilution of 1/75(Cytoplasm and Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human colorectal cancer tissue is first treated with the fusion protein and then with 217589(Anti-TAB1 Antibody) at dilution 1/75.
           引用文献