武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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SMC5 Rabbit pAb

Anti-SMC5 Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S220952

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S220952
产品全名:   SMC5 兔多抗
基因符号   SMC5L1
UNIPROT ID:   Q8IY18 (Gene Accession – NP_055925 )
背景:   Core component of the SMC5-SMC6 comple,x a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6.
抗原:   Synthetic peptide of human SMC5
经过测试的应用:   ELISA, IHC
推荐稀释比:   IHC: 20-100; ELISA: 5000-10000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human, Mouse
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Epigenetics and Nuclear Signaling, Cancer
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human lung cancer tissue using 220952(SMC5 Antibody) at a dilution of 1/30(Nucleus and Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human lung cancer tissue is first treated with the synthetic peptide and then with 220952(Anti-SMC5 Antibody) at dilution 1/30.
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