| 货号: N262865 |
| 产品全名: SAFB1 兔单克隆抗体 |
| 基因符号 SAFB; HAP; HET; SAFB1; Scaffold attachment factor B1; SAF-B; SAF-B1; HSP27 estrogen response element-TATA box-binding protein; HSP27 ERE-TATA-binding 蛋白 |
| UNIPROT ID: Q15424 |
| 背景: This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a ‘transcriptosome complex’ in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene. |
| 抗原: A synthetic peptide of human SAFB |
| 经过测试的应用: WB,IHC-F,IHC-P,ICC/IF |
| 推荐稀释比: WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 |
| 种属反应性: Rabbit |
| 克隆性： Rabbit Monoclonal |
| 克隆编号: R03-7A1 |
| 分子量: Calculated MW: 103 kDa; Observed MW: 150 kDa |
| 亚型: IgG |
| 纯化: Affinity Purified |
| 种属反应性: Human,Mouse |
| 成分: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide |
| 研究领域: Epigenetics and Nuclear Signaling |
| 储存和运输: Store at -20°C. Avoid repeated freezing and thawing |
Immunohistochemistry analysis of paraffin-embedded Human breast cancer tissue using SAFB antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. | 
Immunocytochemistry analysis of SAFB1 (green) in 293 using SAFB1 antibody,and DAPI(blue). | 
Western blot analysis of SAFB in K562, 3T3, Hela lysates using SAFB antibody. | |
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