武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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RBL2 Rabbit pAb

Anti-RBL2 Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S220327

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S220327
产品全名:   RBL2 兔多抗
基因符号   Rb2; P130
UNIPROT ID:   Q08999 (Gene Accession – NP_005602 )
背景:   Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 ‘Lys-20’ trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
抗原:   Synthetic peptide of human RBL2
经过测试的应用:   ELISA, IHC
推荐稀释比:   IHC: 30-150; ELISA: 5000-10000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human, Mouse, Rat
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Epigenetics and Nuclear Signaling, Cancer
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human ovarian cancer tissue using 220327(RBL2 Antibody) at a dilution of 1/45(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with the synthetic peptide and then with 220327(Anti-RBL2 Antibody) at dilution 1/45.
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