武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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RASA1 Rabbit mAb

Anti-RASA1 Rabbit Monoclonal Antibody
5/5

¥2,850.00

货号:N263527

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   N263527
产品全名:   RASA1 兔单克隆抗体
基因符号   GAP; PKWS; RASA; p120; CMAVM; CM-AVM; CMAVM1; RASGAP; p120GAP; p120RASGAP
UNIPROT ID:   P20936
背景:   The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.
抗原:   A synthetic peptide of human RASA1
经过测试的应用:   WB,IHC-P
推荐稀释比:   WB: 1/500-1/1000 IHC: 1/50-1/100
种属反应性:   Rabbit
克隆性:   Rabbit Monoclonal
克隆编号:   R01-1D7
分子量:   Calculated MW: 116 kDa; Observed MW: 140 kDa
亚型:   IgG
纯化:   Affinity Purified
种属反应性:   Human
成分:   PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
研究领域:   Signal Transduction
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded Human lung cancer using RASA1 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Western blot analysis of RASA1 in A549, HL-60, U87-MG lysates using RASA1 antibody.
           引用文献