武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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PPM1A Rabbit pAb

Anti-PPM1A Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S217706

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S217706
产品全名:   PPM1A 兔多抗
基因符号   PP2CA; PP2Calpha; PP2C-ALPHA
UNIPROT ID:   P35813 (Gene Accession – BC026691 )
背景:   The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
抗原:   Fusion protein of human PPM1A
经过测试的应用:   ELISA, IHC
推荐稀释比:   IHC: 100-200; ELISA: 5000-10000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human, Mouse, Rat
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Signal Transduction
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human brain tissue using 217706(PPM1A Antibody) at a dilution of 1/120(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human brain tissue is first treated with the fusion protein and then with 217706(Anti-PPM1A Antibody) at dilution 1/120.
           引用文献