武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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Pellino 1 Rabbit mAb

Anti-Pellino 1 Rabbit Monoclonal Antibody
5/5

¥2,850.00

货号:N262694

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   N262694
产品全名:   Pellino 1 兔单克隆抗体
基因符号   Pellino-related intracellular-signaling molecule; RING-type E3 ubiquitin transferase pellino homolog 1
UNIPROT ID:   Q96FA3
背景:   E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates ‘Lys-63’-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates ‘Lys-48’-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the ‘Thr-182’ phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates ‘Lys-63’-linked ubiquitination of RIPK1 (PubMed:29883609).
抗原:   Recombinant protein of human Pellino 1
经过测试的应用:   WB,IP
推荐稀释比:   WB: 1/500-1/1000 IP: 1/20
种属反应性:   Rabbit
克隆性:   Rabbit Monoclonal
克隆编号:   R07-0E3
分子量:   Calculated MW: 46 kDa; Observed MW: 46 kDa
亚型:   IgG
纯化:   Affinity Purified
种属反应性:   Human,Rat
成分:   PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
研究领域:   Signal Transduction
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of Pellino 1 in rat Brain, Jurkat lysates using Pellino 1 antibody.
           引用文献