武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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PEF1 Rabbit mAb

Anti-PEF1 Rabbit Monoclonal Antibody
5/5

¥2,850.00

货号:N262693

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   N262693
产品全名:   PEF1 兔单克隆抗体
基因符号   penta-EF-hand domain containing 1; ABP32; PEF1A
UNIPROT ID:   Q9UBV8
背景:   Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in endoplasmic reticulum (ER)-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase, the heterodimer formed with PDCD6 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (PubMed:27716508). Its role in the heterodimer formed with PDCD6 is however unclear: some evidences show that PEF1 and PDCD6 work together and promote association between PDCD6 and SEC31 in presence of calcium (PubMed:27716508). Other reports show that PEF1 dissociates from PDCD6 in presence of calcium, and may act as a negative regulator of PDCD6 (PubMed:11278427). Also acts as a negative regulator of ER-Golgi transport; possibly by inhibiting interaction between PDCD6 and SEC31 .
抗原:   A synthetic peptide of human PEF1
经过测试的应用:   WB,IP
推荐稀释比:   WB: 1/500-1/1000 IP: 1/20
种属反应性:   Rabbit
克隆性:   Rabbit Monoclonal
克隆编号:   R09-7F3
分子量:   Calculated MW: 30 kDa; Observed MW: 30 kDa
亚型:   IgG
纯化:   Affinity Purified
种属反应性:   Human, Mouse and Rat
成分:   PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
研究领域:   Cell Biology
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of PEF1 in K562, rat Brain, C6, 3T3, Hela lysates using PEF1 antibody.
           引用文献