武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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NCF4 Rabbit mAb

Anti-NCF4 Rabbit Monoclonal Antibody
5/5

¥2,850.00

货号:N263478

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   N263478
产品全名:   NCF4 兔单克隆抗体
基因符号   NCF; CGD3; P40PHOX; SH3PXD4
UNIPROT ID:   Q15080
背景:   The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
抗原:   A synthetic peptide of human p40-phox
经过测试的应用:   WB,IHC-F,IHC-P,ICC/IF,IP
推荐稀释比:   WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/20
种属反应性:   Rabbit
克隆性:   Rabbit Monoclonal
克隆编号:   R02-3G7
分子量:   Calculated MW: 39 kDa; Observed MW: 39 kDa
亚型:   IgG
纯化:   Affinity Purified
种属反应性:   Human
成分:   PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
研究领域:   
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded Human tonsil using p40phox antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Western blot analysis of p40phox in HL-60, U251 lysates using NCF4 antibody.

Immunocytochemistry analysis of p4phox (green) in hela using p4phox antibody,and DAPI(blue)
           引用文献