| 货号: S216953 |
| 产品全名: MLLT3 兔多抗 |
| 基因符号 AF9; YEATS3 |
| UNIPROT ID: P42568 (Gene Accession – BC036089 ) |
| 背景: Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at ‘Lys-9’ (H3K9cr), and with slightly lower affinity histone H3 crotonylated at ‘Lys-18’ (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated at ‘Lys-9’ (H3K9ac), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114). In the SEC comple,x MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619). |
| 抗原: Fusion protein of human MLLT3 |
| 经过测试的应用: ELISA, IHC |
| 推荐稀释比: IHC: 150-300; ELISA: 5000-10000 |
| 种属反应性: Rabbit |
| 克隆性： Rabbit Polyclonal |
| 亚型: Immunogen-specific rabbit IgG |
| 纯化: Antigen affinity purification |
| 种属反应性: Human, Mouse |
| 成分: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol |
| 研究领域: Epigenetics and Nuclear Signaling |
| 储存和运输: Store at -20°C. Avoid repeated freezing and thawing |
Immunohistochemistry analysis of paraffin embedded Human gastric cancer tissue using 216953(MLLT3 Antibody) at a dilution of 1/155(Nucleus). | 
In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with the fusion protein and then with 216953(Anti-MLLT3 Antibody) at dilution 1/155. |
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