武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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MLH1 Rabbit pAb

Anti-MLH1 Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S216658

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S216658
产品全名:   MLH1 兔多抗
基因符号   FCC2; COCA2; HNPCC; MLH-1; hMLH1; HNPCC2; LYNCH2; MMRCS1
UNIPROT ID:   P40692 (Gene Accession – BC006850 )
背景:   The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC).
抗原:   Fusion protein of human MLH1
经过测试的应用:   ELISA, IHC
推荐稀释比:   IHC: 100-300; ELISA: 5000-10000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human, Mouse, Rat
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Epigenetics and Nuclear Signaling, Cancer
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 216658(MLH1 Antibody) at a dilution of 1/85(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the fusion protein and then with 216658(Anti-MLH1 Antibody) at dilution 1/85.
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