武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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Homer1 Rabbit mAb

Anti-Homer1 Rabbit Monoclonal Antibody
5/5

¥2,850.00

货号:N262354

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   N262354
产品全名:   Homer1 兔单克隆抗体
基因符号   HOMER; SYN47; Ves-1; HOMER1A; HOMER1B; HOMER1C
UNIPROT ID:   Q86YM7
背景:   Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines .
抗原:   Recombinant protein of human Homer1
经过测试的应用:   WB,IP
推荐稀释比:   WB: 1/500-1/1000 IP: 1/20
种属反应性:   Rabbit
克隆性:   Rabbit Monoclonal
克隆编号:   R01-5B7
分子量:   Calculated MW: 40 kDa; Observed MW: 46 kDa
亚型:   IgG
纯化:   Affinity Purified
种属反应性:   Mouse,Rat
成分:   PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
研究领域:   Neuroscience
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of Homer1 in rat Brain lysates using Homer1 antibody.

Western blot analysis of Homer1 in mouse brain lysates using Homer1 antibody.
           引用文献