武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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GRM4 Rabbit pAb

Anti-GRM4 Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S219833

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S219833
产品全名:   GRM4 兔多抗
基因符号   mGlu4, GPRC1D, MGLUR4
UNIPROT ID:   Q14833 (Gene Accession – NP_000832 )
背景:   L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.
抗原:   Synthetic peptide of human GRM4
经过测试的应用:   ELISA, IHC
推荐稀释比:   IHC: 25-100; ELISA: 1000-5000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human, Mouse, Rat
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Signal Transduction, Neuroscience
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human breast cancer tissue using 219833(GRM4 Antibody) at a dilution of 1/15(cytoplasm, Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human breast cancer tissue is first treated with the synthetic peptide and then with 219833(Anti-GRM4 Antibody) at dilution 1/15.
           引用文献