武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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DNMT3B Rabbit pAb

Anti-DNMT3B Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S222317

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S222317
产品全名:   DNMT3B 兔多抗
基因符号   ICF; ICF1; M.HsaIIIB
UNIPROT ID:   Q9UBC3 (Gene Accession – NP_008823 )
背景:   CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
抗原:   Synthetic peptide of human DNMT3B
经过测试的应用:   ELISA, IHC
推荐稀释比:   IHC: 50-100; ELISA: 5000-10000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human, Mouse
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Epigenetics and Nuclear Signaling
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human colorectal cancer tissue using 222317(DNMT3B Antibody) at a dilution of 1/30(Cytoplasm and Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human colorectal cancer tissue is first treated with the synthetic peptide and then with 222317(Anti-DNMT3B Antibody) at dilution 1/30.
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