武汉费斯德生物科技有限公司是美国NewEast Biosciences在中国的办事处。NewEast Biosciences 在十二年前率先研发俩种独特的抗体。这俩种抗体仅仅识别活性的GTP酶或者突变的Oncogene。 GTP酶涉及(1)响应细胞表面受体激活的信号转导,包括跨膜受体,例如介导味觉、嗅觉和视觉的那些,(2)核糖体的蛋白质生物合成,(3)调节细胞分化、增殖、分裂和运动,(4)蛋白质通过膜的易位,(5)细胞内囊泡的运输,以及囊泡介导的分泌和摄取,通过GTP酶控制囊泡外壳组装。Oncogene侧是诱发癌症的基因。
我公司将向你提供以下的独一无二的三种抗体或者试剂盒: (1) 仅识别 GTP酶的活性构型的产品, 它可以让你能够量化GTP酶在细胞中的活性和分布。(2) 识别突变 Oncogene蛋白, 但不认识相应野生型的抗体。 (3) 对 cAMP 和 cGMP 具有超亲和力(无需乙酰化)ELISA检测试剂盒。这些产品被将近一千篇同行评议的文章所引用。
¥2,850.00
货号: N225494 |
产品全名: Cleaved-Caspase 4/5 p20 兔多抗 |
基因符号 TX; Mih1; ICH-2; Mih1/TX; ICEREL-II; ICE(rel)II |
UNIPROT ID: P49662/P51878 |
背景: CASP4 (caspase 4) encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, caspase 4 induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. |
抗原: The antiserum was produced against synthesized peptide derived from human Caspase 4/5. AA range:221-270 |
经过测试的应用: WB,ELISA |
推荐稀释比: WB: 1/500-1/1000 ELISA: 1/10000 |
种属反应性: Rabbit |
克隆性: Rabbit Polyclonal |
分子量: Calculated MW: 43 kDa; Observed MW: 47,22 kDa |
亚型: IgG |
纯化: Affinity Chromatography |
种属反应性: Human |
Modification: Cleaved |
成分: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide |
研究领域: apoptosis – Caspase family |
储存和运输: Store at -20°C. Avoid repeated freezing and thawing |
![]() Western blot analysis of Cleaved-Caspase 4/5 p20 in Jurkat lysates using Caspase 4/5 (p20, Cleaved-Asp270/Asp311) antibody. The lane on the right is blocked with the Caspase 4/5 (p20, Cleaved-Asp270/Asp311) peptide. |