武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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CDK3 Rabbit pAb

Anti-CDK3 Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S213421

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S213421
产品全名:   CDK3 兔多抗
基因符号   
UNIPROT ID:   Q00526 (Gene Accession – NP_001249 )
背景:   This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.
抗原:   Synthetic peptide of human CDK3
经过测试的应用:   ELISA, IHC
推荐稀释比:   IHC: 25-100; ELISA: 1000-5000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human, Mouse
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Epigenetics and Nuclear Signaling, Cancer, Neuroscience
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human lung cancer tissue using 213421(CDK3 Antibody) at a dilution of 1/30(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human lung cancer tissue is first treated with the synthetic peptide and then with 213421(Anti-CDK3 Antibody) at dilution 1/30.
           引用文献