武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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CDK12 Rabbit pAb

Anti-CDK12 Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S220478

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S220478
产品全名:   CDK12 兔多抗
基因符号   CRK7; CRKR; CRKRS
UNIPROT ID:   Q9NYV4 (Gene Accession – NP_055898 )
背景:   Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates ‘Ser-5’ in CTD repeats that are already phosphorylated at ‘Ser-7’, but can also phosphorylate ‘Ser-2’. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
抗原:   Synthetic peptide of human CDK12
经过测试的应用:   ELISA, IHC
推荐稀释比:   IHC: 50-200; ELISA: 5000-10000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human, Mouse, Rat
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Signal Transduction
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human gastric cancer tissue using 220478(CDK12 Antibody) at a dilution of 1/50(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with the synthetic peptide and then with 220478(Anti-CDK12 Antibody) at dilution 1/50.
           引用文献