| 货号: S220413 |
| 产品全名: CABLES2 兔多抗 |
| 基因符号 ik3-2; C20orf150; dJ908M14.2 |
| UNIPROT ID: Q9BTV7 (Gene Accession – NP_112492 ) |
| 背景: Cables2 (Cdk5 and ABL1 enzyme substrate 2), also known as Ik3-2, is a 478 amino acid ubiquitously expressed protein that has a C-terminal cyclin box-containing domain, making it a member of the cyclin protein superfamily. A related protein, Cables, forms a trimolecular complex with Cdk5 and c-Abl in vivo, enhances apoptosis induced by overexpression of p53 and may be a tumor suppressor, due to its chromosomal loss of heterozygosity that is found in certain cancers. Cables2 shares 78% sequence similarity with Cables in the region of the cyclin box-containing domain and, in similar functionality, associates with Cdk3, Cdk5 and c-Abl. However, unlike its close relative, Cables2 also contains an N-terminal region that enhances not only p53-mediated cell death, but also p53-independent cell death. This characteristic suggests that the gene encoding Cables2 may also function as a tumor suppressor gene. |
| 抗原: Synthetic peptide of human CABLES2 |
| 经过测试的应用: ELISA, IHC |
| 推荐稀释比: IHC: 25-100; ELISA: 1000-2000 |
| 种属反应性: Rabbit |
| 克隆性： Rabbit Polyclonal |
| 亚型: Immunogen-specific rabbit IgG |
| 纯化: Antigen affinity purification |
| 种属反应性: Human, Mouse |
| 成分: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol |
| 研究领域: Cancer |
| 储存和运输: Store at -20°C. Avoid repeated freezing and thawing |
Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 220413(CABLES2 Antibody) at a dilution of 1/25(Cytoplasm). | 
In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the synthetic peptide and then with 220413(Anti-CABLES2 Antibody) at dilution 1/25. | 
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using 220413(Anti-CABLES2 Antibody) at a dilution of 1/25. | 
In comparision with the IHC on the left, the same paraffin-embedded Human brain tissue is first treated with synthetic peptide and then with D261496(Anti-CABLES2 Antibody) at dilution 1/25. |
|
