武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

微信:Neweast Biosciences

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Bcr Rabbit mAb

Anti-Bcr Rabbit Monoclonal Antibody
5/5

¥2,850.00

货号:N263236

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   N263236
产品全名:   Bcr 兔单克隆抗体
基因符号   ALL; CML; PHL; BCR1; D22S11; D22S662
UNIPROT ID:   P11274
背景:   A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020]
抗原:   A synthetic peptide of human Bcr
经过测试的应用:   WB,IHC-P,IP
推荐稀释比:   WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20
种属反应性:   Rabbit
克隆性:   Rabbit Monoclonal
克隆编号:   R02-6I0
分子量:   Calculated MW: 143 kDa; Observed MW: 160 kDa
亚型:   IgG
纯化:   Affinity Purified
种属反应性:   Human,Rat
成分:   PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
研究领域:   Signal Transduction
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded Human Brain using Bcr antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Western blot analysis of Bcr in A549, HL-60, U2OS, C6 lysates using Bcr antibody.
           引用文献