| 货号: S221815 |
| 产品全名: ATG2A 兔多抗 |
| 基因符号 |
| UNIPROT ID: Q2TAZ0 (Gene Accession – NP_055919 ) |
| 背景: Atg2A (TG2 autophagy related 2 homolog A) is a 1,938 amino acid protein that belongs to the ATG2 family and may play a role in vesicle assembly. Encoded by a gene that maps to human chromosome 11q13.1, Atg2A is conserved in chimpanzee, dog, cow, mouse and rat, and exists as four alternatively spliced isoforms. Undetected in adult tissues, including heart, brain, placenta, lung, liver and skeletal muscle, Atg2A regulation may act as a distinct indicator of autophagic programmed cell death. Atg2A is upregulated in both etoposide- and doxorubicin-induced apoptosis of HeLa cells, suggesting that Atg2A functions as a novel biomarker of topoisomerase II inhibitor-mediated apoptosis. Atg2A associates with Atg2B, indicating that these two related proteins also functionally interact. Atg2A frameshift mutations are linked to gastric and colorectal carcinomas with high microsatellite instability and may contribute to cancer development by deregulating the autophagy process. Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion. |
| 抗原: Synthetic peptide of human ATG2A |
| 经过测试的应用: ELISA, IHC |
| 推荐稀释比: IHC: 20-100; ELISA: 500-1000 |
| 种属反应性: Rabbit |
| 克隆性： Rabbit Polyclonal |
| 亚型: Immunogen-specific rabbit IgG |
| 纯化: Antigen affinity purification |
| 种属反应性: Human, Mouse |
| 成分: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol |
| 研究领域: Cancer |
| 储存和运输: Store at -20°C. Avoid repeated freezing and thawing |
Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 221815(ATG2A Antibody) at a dilution of 1/20(Cytoplasm). | 
In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the synthetic peptide and then with 221815(Anti-ATG2A Antibody) at dilution 1/20. |
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