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APP(3D7) IgG1 Chimeric mAb

Anti-APP antibody(3D7) IgG1 Chimeric Monoclonal Antibody
5/5

货号:28291

规格: 100 µg

库存状态:In Stock

           产品描述          
货号:   28565
产品全名:   APP(3D7) IgG1 Chimeric 单抗
基因符号   AAA;ABETA;ABPP;AD1;APPI;CTFgamma;CVAP;PN-II;PN2;preA4
描述:   APP antibody(3D7) IgG1 Chimeric 单抗
背景:   This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
经过测试的应用:   Flow Cyt
推荐稀释比:   Flow Cyt 1/100
种属反应性:   Rabbit
亚型:   Rabbit/Human Fc chimeric IgG1
纯化:   Purified from cell culture supernatant by affinity chromatography
种属反应性:   人 APP
成分:   Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
储存和运输:   Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. Flow cytometry analysis with Anti-APP (3D7) mAb on Expi293 cells transfected with human APP (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
           引用文献