武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

微信:Neweast Biosciences

咨询:027 – 63497286 

APH1A Rabbit pAb

Anti-APH1A Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S214980

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S214980
产品全名:   APH1A 兔多抗
基因符号   APH-1; APH-1A; CGI-78; 6530402N02Rik
UNIPROT ID:   Q96BI3 (Gene Accession – NP_057106 )
背景:   This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer’s disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants.
抗原:   Synthetic peptide of human APH1A
经过测试的应用:   ELISA, IHC
推荐稀释比:   IHC: 20-100; ELISA: 2000-5000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human, Mouse
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Neuroscience, Signal Transduction
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 214980(APH1A Antibody) at a dilution of 1/25(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the synthetic peptide and then with 214980(Anti-APH1A Antibody) at dilution 1/25.
           引用文献