武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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Securin Rabbit mAb

Anti-Securin Rabbit Monoclonal Antibody
5/5

¥2,850.00

货号:N262879

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   N262879
产品全名:   Securin 兔单克隆抗体
基因符号   PTTG1; EAP1; PTTG; TUTR1; Securin; Esp1-associated protein; Pituitary tumor-transforming gene 1 protein; Tumor-transforming protein 1; hPTTG
UNIPROT ID:   O95997
背景:   Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.
抗原:   A synthetic peptide of human Securin
经过测试的应用:   WB,IHC-P,IP
推荐稀释比:   WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20
种属反应性:   Rabbit
克隆性:   Rabbit Monoclonal
克隆编号:   R09-6J7
分子量:   Calculated MW: 22 kDa; Observed MW: 25 kDa
亚型:   IgG
纯化:   Affinity Purified
种属反应性:   Human,Mouse
成分:   PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
研究领域:   Cell Biology
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded Human tonsil using Securin antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Western blot analysis of Securin in K562, 3T3, Hela lysates using Securin antibody.
           引用文献