武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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SCIN Rabbit mAb

Anti-SCIN Rabbit Monoclonal Antibody
5/5

¥2,850.00

货号:N262874

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   N262874
产品全名:   SCIN 兔单克隆抗体
基因符号   Scinderin
UNIPROT ID:   Q9Y6U3
背景:   Ca2+-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) . In vitro, also has barbed end capping and nucleating activities in the presence of Ca2+. Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts . Regulates chondrocyte proliferation and differentiation . Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009).
抗原:   A synthetic peptide of human SCIN
经过测试的应用:   WB,IHC-P
推荐稀释比:   WB: 1/500-1/1000 IHC: 1/50-1/100
种属反应性:   Rabbit
克隆性:   Rabbit Monoclonal
克隆编号:   R07-6G2
分子量:   Calculated MW: 80 kDa; Observed MW: 80 kDa
亚型:   IgG
纯化:   Affinity Purified
种属反应性:   Human
成分:   PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
研究领域:   Signal Transduction
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded Human colon cancer using SCIN antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Western blot analysis of SCIN in Hela lysates using SCIN antibody.
           引用文献