| 货号: N261925 |
| 产品全名: BIN1 兔单克隆抗体 |
| 基因符号 BIN1; AMPHL; Myc box-dependent-interacting protein 1; Amphiphysin II; Amphiphysin-like protein; Box-dependent myc-interacting protein 1; Bridging integrator 1 |
| UNIPROT ID: O00499 |
| 背景: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. |
| 抗原: Recombinant protein of human BIN1 |
| 经过测试的应用: WB,IHC-F,IHC-P,ICC/IF |
| 推荐稀释比: WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 |
| 种属反应性: Rabbit |
| 克隆性： Rabbit Monoclonal |
| 克隆编号: R07-2C1 |
| 分子量: Calculated MW: 65 kDa; Observed MW: 45-80 kDa |
| 亚型: IgG |
| 纯化: Affinity Purified |
| 种属反应性: Human, Mouse and Rat |
| 成分: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide |
| 研究领域: Cell Biology |
| 储存和运输: Store at -20°C. Avoid repeated freezing and thawing |
Western blot analysis of BIN1 in rat Brain lysates using BIN1 antibody | 
Immunocytochemistry analysis of BIN1 (green) in U87-MG using BIN1 antibody,and DAPI(blue). | 
Western blot analysis of BIN1 in rat brain, mouse muscle lysates using BIN1 antibody. | 
Immunohistochemistry analysis of paraffin-embedded Human tonsil using BIN1 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. |
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