武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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MBD2-b Rabbit pAb

Anti-MBD2-b Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S221794

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S221794
产品全名:   MBD2-b 兔多抗
基因符号   DMTase; NY-CO-41
UNIPROT ID:   Q9UBB5 (Gene Accession – NP_056647 )
背景:   DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.
抗原:   Synthetic peptide of human MBD2-b
经过测试的应用:   ELISA, IHC
推荐稀释比:   IHC: 20-100; ELISA: 5000-10000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Epigenetics and Nuclear Signaling
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human colorectal cancer tissue using 221794(MBD2-b Antibody) at a dilution of 1/20(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human colorectal cancer tissue is first treated with the synthetic peptide and then with 221794(Anti-MBD2-b Antibody) at dilution 1/20.
           引用文献