| 货号: S221639 |
| 产品全名: RIOX1 兔多抗 |
| 基因符号 ROX; NO66; JMJD9; MAPJD; URLC2; hsNO66; C14orf169 |
| UNIPROT ID: Q9H6W3 (Gene Accession – NP_078920 ) |
| 背景: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates ‘Lys-4’ (H3K4me) and ‘Lys-36’ (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ‘Lys-4’ (H3K4me3) and monomethylated H3 ‘Lys-4’ (H3K4me1) residues, while it has weaker activity for dimethylated H3 ‘Lys-36’ (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on ‘His-216’. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation. |
| 抗原: Synthetic peptide of human RIOX1 |
| 经过测试的应用: ELISA, IHC |
| 推荐稀释比: IHC: 30-150; ELISA: 5000-10000 |
| 种属反应性: Rabbit |
| 克隆性： Rabbit Polyclonal |
| 亚型: Immunogen-specific rabbit IgG |
| 纯化: Antigen affinity purification |
| 种属反应性: Human, Mouse, Rat |
| 成分: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol |
| 研究领域: Epigenetics and Nuclear Signaling |
| 储存和运输: Store at -20°C. Avoid repeated freezing and thawing |
Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 221639(RIOX1 Antibody) at a dilution of 1/45(Nucleus). | 
In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the synthetic peptide and then with 221639(Anti-RIOX1 Antibody) at dilution 1/45. | 
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 221639(Anti-RIOX1 Antibody) at a dilution of 1/45. | 
In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with synthetic peptide and then with D263324(Anti-RIOX1 Antibody) at dilution 1/45. |
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