| 货号: S220184 |
| 产品全名: PTPRM 兔多抗 |
| 基因符号 RPTPM, RPTPU, PTPRL1, hR-PTPu, R-PTP-MU |
| UNIPROT ID: P28827 (Gene Accession – NP_002836 ) |
| 背景: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. |
| 抗原: Synthetic peptide of human PTPRM |
| 经过测试的应用: ELISA, IHC |
| 推荐稀释比: IHC: 100-300; ELISA: 2000-10000 |
| 种属反应性: Rabbit |
| 克隆性： Rabbit Polyclonal |
| 亚型: Immunogen-specific rabbit IgG |
| 纯化: Antigen affinity purification |
| 种属反应性: Human, Mouse |
| 成分: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol |
| 研究领域: Signal Transduction |
| 储存和运输: Store at -20°C. Avoid repeated freezing and thawing |
Immunohistochemistry analysis of paraffin embedded Human esophagus cancer tissue using 220184(PTPRM Antibody) at a dilution of 1/80(Cytoplasm). | 
In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer tissue is first treated with the synthetic peptide and then with 220184(Anti-PTPRM Antibody) at dilution 1/80. | 
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 220184(Anti-PTPRM Antibody) at a dilution of 1/80. | 
In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with synthetic peptide and then with D261098(Anti-PTPRM Antibody) at dilution 1/80. |
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