| 货号: S219905 |
| 产品全名: MC1R 兔多抗 |
| 基因符号 CMM5, MSH-R, SHEP2 |
| UNIPROT ID: Q01726 (Gene Accession – NP_002377 ) |
| 背景: This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. |
| 抗原: Synthetic peptide of human MC1R |
| 经过测试的应用: ELISA, IHC |
| 推荐稀释比: IHC: 50-200; ELISA: 1000-5000 |
| 种属反应性: Rabbit |
| 克隆性： Rabbit Polyclonal |
| 亚型: Immunogen-specific rabbit IgG |
| 纯化: Antigen affinity purification |
| 种属反应性: Human, Mouse |
| 成分: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol |
| 研究领域: Metabolism, Neuroscience |
| 储存和运输: Store at -20°C. Avoid repeated freezing and thawing |
Immunohistochemistry analysis of paraffin embedded Human colon cancer tissue using 219905(MC1R Antibody) at a dilution of 1/100(Cytoplasm). | 
In comparision with the IHC on the left, the same paraffin-embedded Human colon cancer tissue is first treated with the synthetic peptide and then with 219905(Anti-MC1R Antibody) at dilution 1/100. | 
The image on the left is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using 219905(Anti-MC1R Antibody) at a dilution of 1/100. | 
In comparision with the IHC on the left, the same paraffin-embedded Human gasrtic cancer tissue is first treated with synthetic peptide and then with D260588(Anti-MC1R Antibody) at dilution 1/100. |
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