| 货号: S214147 |
| 产品全名: CAV1 兔多抗 |
| 基因符号 CGL3; PPH3; BSCL3; VIP21; MSTP085 |
| UNIPROT ID: Q03135 (Gene Accession – NP_001744 ) |
| 背景: The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1. |
| 抗原: Synthetic peptide of human CAV1 |
| 经过测试的应用: ELISA, WB, IHC |
| 推荐稀释比: IHC: 50-200;WB: 1000-5000;ELISA: 2000-10000 |
| 种属反应性: Rabbit |
| 克隆性： Rabbit Polyclonal |
| 亚型: Immunogen-specific rabbit IgG |
| 纯化: Antigen affinity purification |
| 种属反应性: Human, Mouse, Rat |
| 成分: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol |
| 研究领域: Signal Transduction, Cancer |
| 储存和运输: Store at -20°C. Avoid repeated freezing and thawing |
Immunohistochemistry analysis of paraffin embedded Human esophagus cancer tissue using 214147(CAV1 Antibody) at a dilution of 1/40(Cytoplasm). | 
In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer tissue is first treated with the synthetic peptide and then with 214147(Anti-CAV1 Antibody) at dilution 1/40. | 
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using 214147(Anti-CAV1 Antibody) at a dilution of 1/40. | 
In comparision with the IHC on the left, the same paraffin-embedded Human cervical cancer tissue is first treated with synthetic peptide and then with D161423(Anti-CAV1 Antibody) at dilution 1/40. | 
Gel: 10%SDS-PAGE, Lysate: 40 μg;
Lane 1-6: Human fetal muscle tissue, Human fetal lung tissue, Human leiomyosarcoma tissue, mouse lung, Mouse heart tissue, NIH/3T3 cells;
Primary antibody: 214147(CAV1 Antibody) at dilution 1/550;
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution;
Exposure time: 10 seconds | |
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