武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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TFEB Rabbit pAb

Anti-TFEB Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S217890

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S217890
产品全名:   TFEB 兔多抗
基因符号   TCFEB; BHLHE35; ALPHATFEB
UNIPROT ID:   P19484 (Gene Accession – BC032448 )
背景:   Transcription factor that specifically recognizes and binds E-box sequences (5′-CANNTG-3′). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5′-GTCACGTGAC-3′) present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 bo,x a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937).
抗原:   Fusion protein of human TFEB
经过测试的应用:   ELISA, IHC
推荐稀释比:   IHC: 50-200; ELISA: 5000-10000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human, Mouse
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Epigenetics and Nuclear Signaling
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human tonsil tissue using 217890(TFEB Antibody) at a dilution of 1/80(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human tonsil tissue is first treated with the fusion protein and then with 217890(Anti-TFEB Antibody) at dilution 1/80.

The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 217890(Anti-TFEB Antibody) at a dilution of 1/80.

In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with fusion protein and then with D223310(Anti-TFEB Antibody) at dilution 1/80.
           引用文献