武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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SMC1A Rabbit pAb

Anti-SMC1A Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S217834

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S217834
产品全名:   SMC1A 兔多抗
基因符号   SMC1; SMCB; CDLS2; SB1.8; SMC1L1; DXS423E; SMC1alpha
UNIPROT ID:   Q14683 (Gene Accession – BC112127 )
背景:   Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
抗原:   Fusion protein of human SMC1A
经过测试的应用:   ELISA, IHC
推荐稀释比:   IHC: 30-150; ELISA: 5000-10000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human, Mouse, Rat
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Epigenetics and Nuclear Signaling, Cancer
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human breast cancer tissue using 217834(SMC1A Antibody) at a dilution of 1/45(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human breast cancer tissue is first treated with the fusion protein and then with 217834(Anti-SMC1A Antibody) at dilution 1/45.

The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using 217834(Anti-SMC1A Antibody) at a dilution of 1/45.

In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer tissue is first treated with fusion protein and then with D223183(Anti-SMC1A Antibody) at dilution 1/45.
           引用文献