武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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KDM3B Rabbit pAb

Anti-KDM3B Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S217550

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S217550
产品全名:   KDM3B 兔多抗
基因符号   5qNCA; NET22; C5orf7; JMJD1B
UNIPROT ID:   Q7LBC6 (Gene Accession – BC001202 )
背景:   JMJD1B (jumonji domain containing 1B), also known as KDM3B, 5qNCA (5q Nuclear Co-Activator) or C5orf7, is a member of the JHDM2 histone demethylase family of proteins. Expressed in a wide variety of tissues, JMJD1B localizes to the nucleus and contains one JMJC domain and a C-terminal zinc finger motif. JMJD1B functions as a histone demethylase and, using iron as a cofactor, demethylates lysine-9 of Histone H3. This suggests that JMJD1B plays a central role in the histone code. The gene encoding human JMJD1B is located within the 5q region of the genome that is often deleted in myeloid leukemias and myelodysplasias. This implies that JMJD1B may function as a tumor suppressor of myeloid leukemia. Eptopic expression of JMJD1B exhibits growth suppressive activities, further supporting a role for JMJD1B in tumor suppression.
抗原:   Fusion protein of human KDM3B
经过测试的应用:   ELISA, IHC
推荐稀释比:   IHC: 50-200; ELISA: 2000-5000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human, Mouse
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Epigenetics and Nuclear Signaling, Cancer
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human lung cancer tissue using 217550(KDM3B Antibody) at a dilution of 1/50(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human lung cancer tissue is first treated with the fusion protein and then with 217550(Anti-KDM3B Antibody) at dilution 1/50.

The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using 217550(Anti-KDM3B Antibody) at a dilution of 1/50.

In comparision with the IHC on the left, the same paraffin-embedded Human prostate cancer tissue is first treated with fusion protein and then with D222561(Anti-KDM3B Antibody) at dilution 1/50.
           引用文献