武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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INPP5D Rabbit pAb

Anti-INPP5D Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S217813

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S217813
产品全名:   INPP5D 兔多抗
基因符号   SHIP; SHIP1; SHIP-1; hp51CN; SIP-145; p150Ship
UNIPROT ID:   Q92835 (Gene Accession – BC113580 )
背景:   This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5′ phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants.
抗原:   Fusion protein of human INPP5D
经过测试的应用:   ELISA, IHC
推荐稀释比:   IHC: 200-300; ELISA: 5000-10000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Signal Transduction, Immunology
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human esophagus cancer tissue using 217813(INPP5D Antibody) at a dilution of 1/160(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer tissue is first treated with the fusion protein and then with 217813(Anti-INPP5D Antibody) at dilution 1/160.

The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using 217813(Anti-INPP5D Antibody) at a dilution of 1/160.

In comparision with the IHC on the left, the same paraffin-embedded Human tonsil tissue is first treated with fusion protein and then with D223145(Anti-INPP5D Antibody) at dilution 1/160.
           引用文献