武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处

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INAVA Rabbit pAb

Anti-INAVA Rabbit Polyclonal Antibody
5/5

¥2,850.00

货号:S218400

规格: 100 微升

库存状态:In Stock

           产品描述          
货号:   S218400
产品全名:   INAVA 兔多抗
基因符号   C1orf106
UNIPROT ID:   Q3KP66 (Gene Accession – BC106877 )
背景:   Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262).
抗原:   Fusion protein of human INAVA
经过测试的应用:   ELISA, IHC
推荐稀释比:   IHC: 50-300; ELISA: 5000-10000
种属反应性:   Rabbit
克隆性:   Rabbit Polyclonal
亚型:   Immunogen-specific rabbit IgG
纯化:   Antigen affinity purification
种属反应性:   Human, Mouse
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
研究领域:   Cell Biology
储存和运输:   Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 218400(INAVA Antibody) at a dilution of 1/80(Cytoplasm and Cell membrane).

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the fusion protein and then with 218400(Anti-INAVA Antibody) at dilution 1/80.
           引用文献